65898-38-6

Basic information

• Product Name: INDAN-5-CARBOXYLIC ACID
• Synonyms: ASINEX-REAG BAS 12968513;INDAN-5-CARBOXYLIC ACID;INDANE-5-CARBOXYLIC ACID;TIMTEC-BB SBB010435;5-indanecarboxylic acid(SALTDATA: FREE);5-Indancarboxylic acid;1H-INDENE-5-CARBOXYLIC ACID, 2,3-DIHYDRO
• CAS NO: 65898-38-6
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.19
• Product Categories: pharmacetical
• Mol File: 65898-38-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 184 °C
• Boiling Point: 313.5°Cat760mmHg
• Flash Point: 142.9°C
• Appearance: /
• Density: 1.237g/cm³
• Vapor Pressure: 0.00021mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.44±0.20(Predicted)
• CAS DataBase Reference: INDAN-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: INDAN-5-CARBOXYLIC ACID(65898-38-6)
• EPA Substance Registry System: INDAN-5-CARBOXYLIC ACID(65898-38-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 65898-38-6(Hazardous Substances Data)

Usage

Uses

Indane-?5-?carboxylic Acid (cas# 65898-38-6) is a compound useful in organic synthesis.

InChI:InChI=1/C10H10O2/c11-10(12)9-5-4-7-2-1-3-8(7)6-9/h4-6H,1-3H2,(H,11,12)

Upstream product

• 4228-10-8 1-indan-5-yl-ethanone 
• 41202-24-8 2-chloro-1-indan-5-yl-ethanone 
• 6321-58-0 2-(indan-5-carbonyl)-benzoic acid 
• 113364-54-8 1-(2-indan-5-yl-2-oxo-ethyl)-pyridinium; iodide 
• 30084-91-4 indan-5-carbaldehyde 
• 201230-82-2 carbon monoxide 
• 143287-97-2 2,3-dihydro-1H-inden-5-yl trifluoromethanesulfonate 
• 60-29-7 diethyl ether 
• 6134-54-9 5-bromoindane 
• 7553-56-2 iodine 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 79-37-8 oxalyl dichloride 
• 496-11-7 INDANE 

Downstream Products

• 528-44-9 1,2,4-benzene tricarboxylic acid 
• 86031-43-8 methyl 5-indanecarboxylate 
• 18775-43-4 (5-indanyl)acetonitrile 
• 1415470-61-9 (2S,3R,4R,5S,6R)-2-(7-bromo-6-(4-methoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 1415470-65-3 (2S,3R,4R,5S,6R)-2-(7-chloro-6-(4-methoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 501649-52-1 5-(bromomethyl)-2,3-dihydro-1H-indene 
• 103204-17-7 indan-5-carboxamide 
• 75412-82-7 2,3,4,5,6,7-Hexahydro-1H-indene-5-carbonyl chloride 
• 30084-91-4 indan-5-carbaldehyde 
• 23291-98-7 3-(2.3-Dihydro-1H-inden-5-yl)-propanoic acid 

Relevant articles and documents

Asymmetric Syntheses of Medicinally Important Isoindolinones (S)-PD 172938, (R)-JM 1232, and Related Structures

A unified approach for the asymmetric syntheses of medicinally important isoindolinones (S)-PD 172938 and (R)-JM 1232 has been accomplished via a Cu(I)-PYBOX-diPh catalyzed highly enantioselective (up to 99% ee) alkynylation/lactamization sequence in a one-pot fashion. The overall sequence involves one C-C and two C-N bond forming events in one pot starting from inexpensive starting material in ambient reaction conditions.

As a new polyphenylenepolymethylenepolyisocyanate deriv. SGLT2 inhibitor

A compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney is disclosed. A pharmaceutical composition including the compound as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes is disclosed. A method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound is provided.

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.