232950-92-4

Upstream product

• 140373-77-9 tert-butyl 2-fluoro-4-aminobenzoate 
• 324789-64-2 2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester 
• 324789-00-6 tert-butyl 4-(5-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluoro-benzoate 
• 324788-99-0 5-(R)-hydroxymethyl-3-[4'-tert-butoxycarbonyl-3'-fluorophenyl]oxazolidine-2-one 
• 232951-33-6 5-(S)-(N-Acetylaminomethyl)-3-[4'-(tert-butoxy)carbonyl-3'-fluorophenyl]-oxazolidine-2-one 
• 403-23-6 2-fluoro-4-nitrobenzoyl chloride 

Downstream Products

• 232950-93-5 5-(S)-acetamidomethyl-3-[4'-(pentafluorophenyl)oxycarbonyl-3'-fluorophenyl]-oxazolidine-2-one 
• 232951-47-2 5-(S)-Acetamidomethyl-3-[4'-(6-methoxybenzothiazole-2-yl)aminocarbonyl-3'-fluorophenyl]-oxazolidine-2-one 
• 1087353-39-6 (S)-N-{3-[3-fluoro-4-(3-[1,2,4]triazol-1-ylmethyl-[1,2,4]oxadiazol-5-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 232951-46-1 5-(S)-Acetamidomethyl-3-[4'-(benzothiazole-2-yl)aminocarbonyl-3'-fluorophenyl]-oxazolidine-2-one 
• 741294-15-5 (S)-N-[[3-[3-fluoro-4-[N-1-(4-t-butoxycarbonyl) piperazinylcarbonyl] phenyl]-2-oxo-5-oxazolidinyl] methyl]-acetamide 

Relevant academic research and scientific papers

Novel oxazolidinone-quinolone hybrid antimicrobials

Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2, 5, and 6 display an improved potency versus linezolid against gram-positive and fastidious gram-negative pathogens. The compounds are also active against linezolid- and ciprofloxacin-resistant Staphylococcus aureus and Enterococcus faecium strains. The MOA for these new antimicrobials is consistent with a combination of protein synthesis and gyrase A/topoisomerase IV inhibition, with a structure-dependent degree of the contribution from each inhibitory mechanism.