232950-93-5

Upstream product

• 14533-84-7 pentafluorophenyl trifloroacetate 
• 232950-92-4 5-(S)-Acetamidomethyl-3-[4'-carboxy-3'-fluorophenyl]-oxazolidine-2-one 
• 1427-07-2 2-fluoro-4-nitrotoluene 
• 403-24-7 2-fluoro-4-nitrobenzoic acid 
• 140373-77-9 tert-butyl 2-fluoro-4-aminobenzoate 
• 324788-99-0 5-(R)-hydroxymethyl-3-[4'-tert-butoxycarbonyl-3'-fluorophenyl]oxazolidine-2-one 
• 232951-33-6 5-(S)-(N-Acetylaminomethyl)-3-[4'-(tert-butoxy)carbonyl-3'-fluorophenyl]-oxazolidine-2-one 
• 324789-64-2 2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester 
• 324789-00-6 tert-butyl 4-(5-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluoro-benzoate 
• 324788-98-9 tert-butyl 4-benzyloxycarbonylamino-2-fluoro-benzoate 

Downstream Products

• 232950-95-7 5-(S)-Acetamidomethyl-3-[4'-(3-pyridylamino)carbonyl-3'-fluorophenyl]-oxazolidine-2-one 
• 232951-55-2 5-(S)-acetamidomethyl-3-[4'-(N-hydroxyamino)carbonyl-3'-fluorophenyl]oxazolidine-2-one 
• 324788-74-1 5-(S)-acetamidomethyl-3-[4'-(hydrazino)carbonyl-3'-fluorophenyl]oxazolidine-2-one 

Relevant academic research and scientific papers

Novel oxazolidinone-quinolone hybrid antimicrobials

Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2, 5, and 6 display an improved potency versus linezolid against gram-positive and fastidious gram-negative pathogens. The compounds are also active against linezolid- and ciprofloxacin-resistant Staphylococcus aureus and Enterococcus faecium strains. The MOA for these new antimicrobials is consistent with a combination of protein synthesis and gyrase A/topoisomerase IV inhibition, with a structure-dependent degree of the contribution from each inhibitory mechanism.

Oxazolidinone compounds and compositions, and methods of using the same

Oxazolidinones and methods for their synthesis are provided. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. Oxazolidinones as disclosed herein can be readily synthesized and used in a variety of applications including use as antimicrobial agents. In one embodiment, a variety of thioamidomethyloxazolidinones and methods for their synthesis and use are provided.