23301-00-0Relevant academic research and scientific papers
Unorthodox cascade reaction of arynes and: N -nitrosamides leading to indazole scaffolds
Baidya, Mahiuddin,Bhajammanavar, Vinod,Choutipalli, Venkata Surya Kumar,Subramanian, Venkatesan,Sureshbabu, Popuri
supporting information, p. 1187 - 1190 (2022/02/03)
An unusual cascade annulation of arynes with N-alkyl-N-nitrosamides is developed by leveraging aryne σ-insertion and C(sp3)-H bond functionalization strategies under transition-metal-free conditions at ambient temperature, offering functionalized indazoles in high yields and regioselectivity. The protocol is scalable and exhibits a broad substrate scope. The reaction mechanism is also studied with DFT calculations.
Selective N1-Acylation of Indazoles with Acid Anhydrides Using an Electrochemical Approach
DIssanayake, D.M.M. Mevan,Vannucci, Aaron K.
supporting information, p. 457 - 460 (2019/01/23)
An electrochemical synthesis method for the selective N1-acylation of indazoles has been developed. This "anion pool" approach electrochemically reduces indazole molecules generating indazole anions and H2. Acid anhydrides are then introduced to the solution resulting in selective acylation of the N1-position of the indazoles. This procedure can also be applied to the acylation of benzimidazoles and indoles. The reaction can also be performed using a 9 V battery without loss of reaction efficiency.
