81265-90-9Relevant academic research and scientific papers
Room-Temperature, Metal-Free, and One-Pot Preparation of 2H-Indazoles through a Mills Reaction and Cyclization Sequence
Kondo, Masaru,Takizawa, Shinobu,Jiang, Yuzhao,Sasai, Hiroaki
, p. 9866 - 9869 (2019)
The Mills reaction and cyclization of readily available 2-aminobenzyl alcohols and nitrosobenzenes using thionyl bromide provided 2H-indazoles in up to 88 % yields. In the metal-free process, acetic acid played a crucial role for the both Mills reaction and cyclization. A brominated 2H-indazole could also be obtained through the one-pot sequence.
Regioselective C3-H Trifluoromethylation of 2 H-Indazole under Transition-Metal-Free Photoredox Catalysis
Murugan, Arumugavel,Babu, Venkata Nagarjuna,Polu, Ashok,Sabarinathan, Nagaraj,Bakthadoss, Manickam,Sharada, Duddu S.
, p. 7796 - 7803 (2019/06/27)
Trifluoromethyl-substituted heteroarenes are biologically active compounds and useful building blocks. In this sequence, we have developed a visible-light-promoted regioselective C3-H trifluoromethylation of 2H-indazole under metal-free conditions, which
