23316-68-9Relevant articles and documents
COMPOUNDS AS CD73 INHIBITORS
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, (2021/05/15)
Provided herein are the compounds that are inhibitors of CD73 and are useful in treating CD73-associated diseases or conditions. Compositions containing the compounds are also provided.
Highly stereoselective synthesis of aryl/heteroaryl-: C -nucleosides via the merger of photoredox and nickel catalysis
Ma, Yingying,Liu, Shihui,Xi, Yifan,Li, Hongrui,Yang, Kai,Cheng, Zhihao,Wang, Wei,Zhang, Yongqiang
, p. 14657 - 14660 (2019/12/11)
A photoredox/nickel dual-catalyzed decarboxylative cross-coupling reaction of anomeric ribosyl/deoxyribosyl acids with aryl/heteroaryl bromides has been developed. The reaction proceeds smoothly under visible-light irradiation and features the using of cost-effective and easily handled catalysts and starting materials, which allows the highly stereoselective synthesis of diverse aryl/heteroaryl-C-nucleosides in moderate to high yields.
Synthesis of C-ribosyl 1,2,4-triazolo[3,4-f][1,2,4]triazines as inhibitors of adenosine and AMP deaminases
Dudfield, Philip J.,Le, Van-Duc,Lindell, Stephen D.,Rees, Charles W.
, p. 2937 - 2942 (2007/10/03)
Modified C-nucleosides and nucleotides with an enhanced tendency to undergo covalent hydration are of interest as potential inhibitors of adenosine deaminase (ADA) and AMP deaminase, respectively. In a search for such compounds we have synthesized 6-dimet
Synthesis of 1-chloroacetyl-1-dehydroxy-2,3,5-tri-O-benzoyl-β-D-ribofuranose. A potentially versatile intermediate for the synthesis of C-nucleosides
Han,Lee,Kang,Kim,Chi
, p. 2815 - 2822 (2007/10/02)
New key carbohydrate intermediate, 1-chloroacetyl-1-dehydroxy-2,3,5-tri-O-benzoyl-β-D-ribofuranose (1a) has been synthesized. The application of this key intermediate would be very wide. We have very conveniently synthesized several C-nucleosides includin