23337-77-1Relevant academic research and scientific papers
Synthese de 2,3,4,4a,9,9a-Hexahydro-11-indenopyrazines, Analogues Rigides de 3-Methyl-2-phenylpiperazines et Antidepresseurs Potentiels
Chahboun, S.,Gelbcke, M.,Vliedt, G. Van De,Smith, D. F.
, p. 287 - 296 (2007/10/03)
The synthesis of various diastereoisomeric (+/-) trans-(VIII) and cis-2,3,4,4a,9,9a-hexahydro-1H-indenopyrazines (IX) is described, using as key step for piperazine ring formation an alkoxyphosphonium salt.Compound VIIIa was prepared as a potential serotonin reuptake inhibitor.
1,4-Oxazines via Intramolecular Ring Closure of β-Hydroxydiazoacetamides: Phenylalanine to Tetrahydroindeno-1,4-oxazin-3(2H)-ones
McClure, D. E.,Lumma, P. K.,Arison, B. H.,Jones, J. H.,Baldwin, J. J.
, p. 2675 - 2679 (2007/10/02)
The synthesis of the tetrahydroindeno-1,4-oxazin-3(2H)-one system from phenylalanine is described.Conversion of the intermediate vicinal amino alcohol to the 1,4-oxazine was accomplished via BF3*Et2O-catalyzed ring closure of a β-hydroxydiazoacetam
