77357-58-5Relevant academic research and scientific papers
A polymer-supported rhodium catalyst that functions in polar protic solvents
Taylor, Rebecca A.,Santora, Brian P.,Gagne, Michel R.
, p. 1781 - 1783 (2007/10/03)
(matrix presented) Highly cross-linked macroporous polymers are excellent supports for heterogenizing rhodium alkene hydrogenation and hydroboration catalysts. The permanent pore structure of the support enables high conversions and excellent yields with minimal workup (filtering). These heterogenized catalysts can be reused, and due to the permanent pore structure, they function in a broad range of solvents including polar protic. Control experiments reveal that catalysis occurs exclusively within the polymer matrix, and not due to leached catalyst.
Design and synthesis of a targeted set of aromatic amino acid derivatives for identification of new lead compounds.
Horwell,Kneen,Pritchard,Ratcliffe,Roberts,Suman-Chauhan,Steiner,Betche
, p. 1957 - 1962 (2007/10/03)
A targeted set of 256 aromatic α-amino acid derivatives is described to provide new lead compounds for biological screening. The utility is exemplified by identification of ligands for the human neuromedin B (hNMB) receptor, such as compound 3 (Ki hNMB 37nM).
1,4-Oxazines via Intramolecular Ring Closure of β-Hydroxydiazoacetamides: Phenylalanine to Tetrahydroindeno-1,4-oxazin-3(2H)-ones
McClure, D. E.,Lumma, P. K.,Arison, B. H.,Jones, J. H.,Baldwin, J. J.
, p. 2675 - 2679 (2007/10/02)
The synthesis of the tetrahydroindeno-1,4-oxazin-3(2H)-one system from phenylalanine is described.Conversion of the intermediate vicinal amino alcohol to the 1,4-oxazine was accomplished via BF3*Et2O-catalyzed ring closure of a β-hydroxydiazoacetam
