23338-78-5Relevant academic research and scientific papers
Photoswitchable hydride transfer from iridium to 1-methylnicotinamide rationalized by thermochemical cycles
Barrett, Seth M.,Pitman, Catherine L.,Walden, Andrew G.,Miller, Alexander J. M.
supporting information, p. 14718 - 14721 (2014/12/11)
Visible light-triggered hydride transfer from [CpIr(bpy)(H)]+ (1) to organic acids and 1-methylnicotinamide (MNA+) is reported (Cp = pentamethylcyclopentadienyl; bpy = 2,2′-bipyridine). A new thermochemical cycle for determining excited-state hydride donor ability (hydricity) predicted that 1 would be an incredibly potent photohydride in acetonitrile. Phototriggered H2 release was indeed observed from 1 in the presence of various organic acids, providing experimental evidence for an increase in hydricity of at least 18 kcal/mol in the excited state. The rate and product selectivity of hydride transfer to MNA+ are photoswitchable: 1,4-dihydro-1-methylnicotinamide forms slowly in the dark but rapidly under illumination, and photolysis can also produce doubly reduced 1,4,5,6-tetrahydro-1-methylnicotinamide.
Dithionite adducts of pyridinium salts: Regioselectivity of formation and mechanisms of decomposition
Carelli, Vincenzo,Liberatore, Felice,Scipione, Luigi,Di Rienzo, Barbara,Tortorella, Silvano
, p. 10331 - 10337 (2007/10/03)
1H and 13C NMR spectroscopy has been used to detect and to characterize the adducts formed, in alkaline solutions, by the attack of dithionite anion on 3-carbamoyl or 3-cyano substituted pyridinium salts. In all studied cases, only 1,4-dihydropyridine-4-sulfinates, formed by attack of dithionite oxyanion on the carbon 4 of pyridinium ring, were found. This absolute regioselectivity seems to suggest a very specific interaction between the pyridinium cation and the dithionite through the formation of a rigidly oriented ion pair, determining the position of attack. In weak alkaline solution, the adducts decompose according to two mechanisms SNi and SNi′: the SNi path is operative in all studied cases and preserves the 1,4-dihydro structure yielding the corresponding 1,4-dihydropyridines, whereas the SNi′ path involves the shift of 2,3 or 5,6 double bonds yielding 1,2- or 1,6-dihydropyridines, respectively. The formation of 1,2- or 1,6-dihydropyridines, in addition to 1,4-dihydro isomers, depends on their respective thermodynamic stabilities.
