6456-44-6Relevant articles and documents
Metal-free reduction of unsaturated carbonyls, quinones, and pyridinium salts with tetrahydroxydiboron/water
Li, Tiejun,Peng, Henian,Tang, Wenjun,Tian, Duanshuai,Xu, Guangqing,Yang, He
, p. 4327 - 4337 (2021/05/31)
A series of unsaturated carbonyls, quinones, and pyridinium salts have been effectively reduced to the corresponding saturated carbonyls, dihydroxybenzenes, and hydropyridines in moderate to high yields with tetrahydroxydiboron/water as a mild, convenient, and metal-free reduction system. Deuterium-labeling experiments have revealed this protocol to be an exclusive transfer hydrogenation process from water. This journal is
An improved method for the quaternization of nicotinamide and antifungal activities of its derivatives
Siber, Tamara,Bu?i?, Valentina,Zobund?ija, Dora,Roca, Sun?ica,Viki?-Topi?, Dra?en,Vrande?i?, Karolina,Ga?o-Soka?, Dajana
, (2019/03/26)
The quaternization reactions of nicotinamide, with different electrophiles: methyl iodide and substituted 2-bromoacetophenones (4-Cl, 4-Br, 4-H, 4-CH3, 4-F, 4-OCH3, 4-Ph, 2-OCH3, 4-NO2) are reported. The preparations were carried out by conventional synthesis and under microwave irradiation in absolute ethanol and acetone. The synthesis performed by microwave dielectric heating significantly improved yield, up to 8 times, and shortened down the reaction time from ca. one day in conventional, to 10–20 min. The structures of the synthesized compounds were confirmed by IR, 1H- and 13C-NMR spectroscopy, mass spectrometry and elemental analysis. The compounds have been screened for antifungal activities against Fusarium oxysporum, Fusarium culmorum, Macrophomina phaseolina and Sclerotinia sclerotiorum at concentrations of 10 μg/mL and 100 μg/mL. Six compounds showed the strong inhibition of mycelium growth at a concentration of 10 μg/mL. All tested compounds revealed the great inhibitory activities against S. sclerotiorum at a concentration of 100 μg/mL.
Substituent effects on formation of cation dimers by weak hydrogen bonds in crystals of carbonyl pyridinium salts of ni(dmit)2
Tomono, Kazuaki,Koyano, Ayako,Morita, Takashi,Miyamura, Kazuo
experimental part, p. 1152 - 1159 (2009/12/25)
Five 1:1 salts of 3-X-1-methylpyridinium (X = benzoyl, acetyl, methoxycarbonyl, carboxy, and aminocarbonyl; abbreviated as Ben, Ace, Met, Car, and Ami, respectively) cations with a [Ni(dmit)2]- anion ([Ben]+[Ni(dmit)2]- (1), Ace] +[Ni(dmit)2]- (2), [Met]+[Ni(dmit) 2]- (3), [Car]+[Ni(dmit)2] - (4), and [Ami]+[Ni(dmit)2]- (5)) have been synthesized and characterized by single-crystal X-ray analysis and conductivity measurements. In the crystals, three cations 1-3 were found to form dimers by weak C-H...O hydrogen bonds, and the arrangements of cations had a strong relation with the electronic effect of the substituents. The cations of 1-3 formed similar centrosymmetrically associated dimers constructed by weak C-H...O hydrogen bonds, whose geometric parameters had a correlation with the electronic effect of the substituents. A cation of 4 also formed centrosymmetrically associated dimer, but it was made by an O-H...O hydrogen bond as usually observed in the case of carboxylic acid. In contrast with other complex salts, cations of 5 formed one-dimensional structure by C-H...O hydrogen bonding. The conductivities of salts 1, 2, 3, 4, and 5 at room temperature were 1.00 × 10-6, 1.10 × 10-6, 2.86 × 10-6, 9.77 × 10-6, and 8.75 × 10 -7Scm-1, respectively.
