23343-31-9

Upstream product

• 108-86-1 bromobenzene 
• 35928-65-5 (methylthio)acetyl chloride 
• 99-73-0 para-bromophenacyl bromide 
• 5188-07-8 sodium thiomethoxide 
• 556-64-9 methyl thiocyanate 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 1007895-40-0 α-Chloro-4-bromophenacyl methyl sulfide 
• 1391948-67-6 (4-bromophenyl)ethynyl methyl sulfide 
• 937161-54-1 C₉H₁₀BrNOS 
• 393085-11-5 2-[4-Bromobenzoyl(methylsulfanyl)methyl]-3,4-dimethylthiophene 
• 393085-12-6 2-(4-Bromophenacyl)-3,4-dimethylthiophene 
• 128080-99-9 2-[1-(4-Bromobenzoyl)ethyl]-3,4-dimethylthiophene 
• 122831-05-4 ethyl 6-phenyl-6-oxo-5-methylthio-2-dimethylamino-2,4-hexadienoate 

Relevant academic research and scientific papers

Rh/DuanPhos-Catalyzed Asymmetric Hydrogenation of β-Acetylamino Vinylsulfides: An Approach to Chiral β-Acetylamino Sulfides

Rh/DuanPhos-catalyzed asymmetric hydrogenation of challenging β-acetylamino vinylsulfides has been developed, affording chiral β-acetylamino sulfides with high yields and excellent ee's (up to 99% ee). This novel methodology provides an efficient and concise synthetic route to chiral β-acetylamino sulfides. The potential utility of this protocol in the synthesis of Apremilast has also been disclosed.

One-pot preparation of arylethynyl sulfides and bis(arylethynyl) sulfides

An efficient preparation for arylethynyl sulfides 1 and bis(arylethynyl) sulfides 2 has been accomplished through a one-pot, three-step strategy that starts from arylethanonyl sulfides and bis(arylethanonyl) sulfides, respectively, without the use of various terminal arylacetylenes as substrates. When lithium hexamethyldisilazane (LHMDS), ClP(O)(OEt)2, and LHMDS were sequentially added to a tetrahydrofuran solution of different substrates [arylethanonyl sulfides or bis(arylethanonyl) sulfides], 1 or 2 were obtained in moderate to good yields. The reaction procedure involves the formation of an enol phosphate and a subsequent base-induced elimination. An efficient preparation of arylethynyl sulfides 1 and bis(arylethynyl) sulfides 2 has been accomplished by a one-pot, three-step strategy that starts from arylethanonyl sulfides and bis(arylethanonyl) sulfides, respectively, to give 1 and 2 in moderate to good yields. The reaction mechanism involves the formation of an enol phosphate that undergoes a subsequent base-induced elimination. Copyright

Reaction of ammonium ylides with alkyl thiocyanates in aqueous and non-aqueous media

Reaction of ammonium ylides with alkyl thiocyanates in aqueous and non-aqueous media is described. The reaction leads to alkyl thio-substituted acetophenones via addition of ammonium ylides to alkyl thiocyanates in organic solvents or in situ generated thiolate anions in aqueous media.

Alkadiene derivatives, their preparation, and pharmaceutical compositions containing them

Substituted alkadienes of the formula: STR1 in which R1 is hydroxy or acetoxy, R2 is hydrogen, carboxy, alkoxycarbonyl, phenyl or benzoyl, and R3 is alkylthio or alkoxy and R4 is naphthoyl or optionally substituted benzoyl, or R3 is alkoxycarbonyl, cycloalkyloxycarbonyl or cyano and R4 is alkyl, naphthyl, optionally substituted phenyl, alkylthio, naphthylmethanethio, optionally substituted benzylthio, optionally substituted phenylthio, naphthylthio, phenethylthio or allylthio, or R3 and R4 form, with the carbon atom to which they are attached, a ring-system of formula: STR2 in which R5 is hydrogen or alkoxy and X is methylene or S inhibit 5-lipoxygenase and are useful, for example, as anti-inflammatories.

A CONVENIENT GENERAL ACCESS TO α-SULFENYLATED ACETOPHENONES AND ALKANONES

Friedel-Crafts acylation of arenes with methylthio- (1) or phenylthio-acetyl chloride (2) provides ready access to α-methylthio- or α-phenylthio-substituted acetophenones.The acyl chlorides 1 and 2 reacted also with organoaluminium reagents to give α-sulfenylated alkanones.