23352-58-1

Upstream product

• 116-31-4 all-trans-Retinal 
• 76985-04-1 9-cis-13-trans-dimethyl-7-(1,1,5-trimethyl-5-cyclohexen-6-yl)-7,9,11,13-nonatetraene-15-nitrile 
• 137068-84-9 2-((1E,3Z)-6,6-Dibromo-3-methyl-hexa-1,3,5-trienyl)-1,3,3-trimethyl-cyclohexene 
• 76929-15-2 (5Z,7E)-6-Methyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-5,7-dien-3-yn-2-ol 
• 54226-17-4 (2Z,4E)-3-methyl-5-[2,6,6-trimethylcyclohex-1-enyl]penta-2,4-dienal 

Downstream Products

• 137121-56-3 Hexadecanoic acid (2E,4Z,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester 
• 137121-55-2 Acetic acid (2E,4Z,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester 
• 137047-37-1 Hexadecanoic acid (1S,6S,7R,8S)-2,6-dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-bicyclo[4.2.0]octa-2,4-dien-7-ylmethyl ester 
• 137047-36-0 Acetic acid (1S,6S,7R,8S)-2,6-dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-bicyclo[4.2.0]octa-2,4-dien-7-ylmethyl ester 
• 93380-02-0 (9Z,11Z)-Retinol 
• 67711-05-1 9-cis,11-cis-retinal 
• 43219-27-8 (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-amine 

Relevant academic research and scientific papers

Ligand binding induces conformational changes in human cellular retinol-binding protein 1 (CRBP1) revealed by atomic resolution crystal structures

Important in regulating the uptake, storage, and metabolism of retinoids, cellular retinol-binding protein 1 (CRBP1) is essential for trafficking Vitamin A through the cytoplasm. However, the molecular details of ligand uptake and targeted release by CRBP

METHODS FOR TREATMENT OF RETINAL DEGENERATIVE DISEASE

A method is provided for treating a degenerative disease in a vertebrate eye. A method is further provided for preventing photoreceptor degeneration in a vertebrate eye.

Preparation of (9Z, 11Z) - Vitamin A

Starting from (7E,9Z)-C15-aldehyde 4, the syntheses of (9Z, 11Z)-vitamin A acetate and palmitate are reported. The construction strategy is based on treatment of 4 with Zn-PPh3/CBr4, addition of acetaldehyde followed by a