23357-47-3 Usage
Uses
Used in Pharmaceutical Industry:
(R)-1,2,3,4-Tetrahedro-naphthoic acid is used as an intermediate in the preparation of Dipeptidyl Boronate Proteasome Inhibitors. These inhibitors play a crucial role in the development of drugs targeting various diseases, including cancer, by disrupting the function of proteasomes, which are essential for protein degradation and cellular regulation.
(R)-1,2,3,4-Tetrahedro-naphthoic acid is also used as a palonosetron intermediate. Palonosetron is a selective 5-HT3 receptor antagonist used to treat nausea and vomiting associated with chemotherapy. The compound's unique structure allows for the development of more effective and targeted pharmaceutical agents.
Used in Chemical Industry:
(R)-1,2,3,4-Tetrahedro-naphthoic acid is used for the construction of sterically constrained protein turn models. These models are essential in understanding protein folding and function, which can lead to the development of new drugs and therapies for various diseases. The compound's rigid structure and chemical properties make it an ideal candidate for creating these models and furthering our understanding of protein dynamics.
Check Digit Verification of cas no
The CAS Registry Mumber 23357-47-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,3,5 and 7 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 23357-47:
(7*2)+(6*3)+(5*3)+(4*5)+(3*7)+(2*4)+(1*7)=103
103 % 10 = 3
So 23357-47-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H12O2/c12-11(13)10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10H,3,5,7H2,(H,12,13)/t10-/m1/s1
23357-47-3Relevant academic research and scientific papers
Method for preparing (S)-tetrahydro-1-naphthoic acid through high-efficiency resolution
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Paragraph 0006; 0015; 0017, (2018/03/13)
The invention relates to a preparation method of a palonosetron hydrochloride key intermediate (S)-1,2,3,4-tetrahydro-1-naphthoic acid as shown in a formula (I). The method comprises the following steps of adding a resolution agent for resolution by adopting 1,2,3,4-tetrahydro-naphthalene acid racemate as a raw material to obtain a salt (III) formed by a (S)-1,2,3,4-tetrahydro naphthalene acid and the resolution agent, and a salt (IV) formed by (R)-1,2,3,4-tetrahydro naphthalene acid and the resolution agent; carrying out salt removing on a compound III and a compound IV separately to obtain compounds (I) and (II); and carrying out racemization on the compound (II) under an alkaline condition to obtain a starting material 1,2,3,4-tetrahydro-naphthalene acid racemate and further carrying out resolution according to the steps. Therefore, the overall yield can be greatly improved, the production cost is reduced and environmental protection is facilitated. The preparation technology of the palonosetron hydrochloride key intermediate provided by the invention is different from the prior art, is safe, environmentally friendly, simple in operation and high in yield, and has relatively great practical value. The formula is as shown in the specification.
