23359-42-4Relevant academic research and scientific papers
Mechanically activated ring-opening reactions of N-acyl-1,2,3,4-tetrahydroisoquinolines derived from the synthesis of praziquantel intermediate
Yu, Jingbo,Wang, Zhi,Zhang, Yang,Su, Weike
, p. 6116 - 6123 (2015/08/03)
Abstract An unexpected DDQ-promoted ring-opening reaction of N-chloroacetyl-tetrahydroisoquinoline under ball milling conditions was revealed during the synthesis of Praziquantel. A variety of N-acyl-tetrahydroisoquinolines were then tested to further inv
Asymmetric intramolecular aza-Michael reaction using environmentally friendly organocatalysis
Takasu, Kiyosei,Maiti, Soumen,Ihara, Masataka
, p. 51 - 55 (2007/10/03)
This communication describes enantioselective intramolecular aza-Michael reaction to prepare 1,2,3,4-tetrahydroisoquinolines by using organocatalysts. The organocatalytic reaction offers new green chemical process in heterocyclic chemistry. Additional not
IMPROVED SYNTHESIS OF DIHYDROISOQUINOLINE REISSERT COMPOUNDS
Jackson, Yvette A.,Stephenson, E. Kyle,Cava, Michael P.
, p. 1047 - 1050 (2007/10/02)
Conversion of a series of 3,4-dihydroisoquinolines to their corresponding Reissert compounds was improved significantly over the usual reaction conditions by buffering the reaction medium at pH 8.
