233600-08-3Relevant articles and documents
Synthesis of ascomycin and FK 506 derivatives with modified effector domain
Nussbaumer, Peter,Grassberger, Maximilian A.,Schulz, Gerhard
, p. 3869 - 3872 (1999)
Oxidation of the 22-hydrazone of ascomycin using manganese dioxide generates in situ the reactive 22-diazo intermediate, which decomposes to give ascomycin analogues with modified effector region. In dichloromethane several products are obtained, whereas in methanol a cyclopropane derivative is generated as the main product starting from the hydrazone of both ascomycin and FK 506.