
Tetrahedron Letters p. 3869 - 3872 (1999)
Update date:2022-08-03
Topics:
Nussbaumer, Peter
Grassberger, Maximilian A.
Schulz, Gerhard
Oxidation of the 22-hydrazone of ascomycin using manganese dioxide generates in situ the reactive 22-diazo intermediate, which decomposes to give ascomycin analogues with modified effector region. In dichloromethane several products are obtained, whereas in methanol a cyclopropane derivative is generated as the main product starting from the hydrazone of both ascomycin and FK 506.
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