233607-99-3

Upstream product

• 109-65-9 1-bromo-butane 
• 180399-97-7 [1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-phosphoramidic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis of α-arylalkylamines by addition of Grignard reagents to N- (diethoxyphosphoryl)aldimines

Addition of organomagnesium bromides to N-(diethoxyphosphoryl) aldimines 1 carded out in tetrahydrofuran at 20-25°C affords diethyl N-alkyl- phosphoramidates 2a-w in high yields and spectroscopic purity. Deprotection of the latent amino groups in 2 results in the formation of α-arylalkylamine hydrochlorides 3a-w.