23378-88-3

Usage

Uses

Used in Pharmaceutical Synthesis:
3,5-Dichloro-2-hydroxybenzenesulfonyl chloride is used as a synthetic intermediate for the production of (1R,2R)-(+)-1,2-(3,3',5,5'-tetrachloro-2,2'-dihydroxydibenzenesulfonamido)-1,2-diphenylethane and (1R,2R)-(+)-1,2-(3,3',5,5'-tetrachloro-2,2'-dihydroxydibenzenesulfonamido)cyclohexane. These compounds have potential applications in the pharmaceutical industry.
Used in Analytical Chemistry:
3,5-Dichloro-2-hydroxybenzenesulfonyl chloride is used as a chromogenic system in a one-step kinetic method for the determination of 5'-nucleotidase. This application is valuable in the field of analytical chemistry for the detection and quantification of specific enzymes.

InChI:InChI=1/C6H3Cl3O3S/c7-3-1-4(8)6(10)5(2-3)13(9,11)12/h1-2,10H

Upstream product

• 120-83-2 2,4-dichlorophenol 

Downstream Products

• 90286-90-1 3,5-Dichloro-N-(2,4-dichloro-phenyl)-2-hydroxy-benzenesulfonamide 
• 269746-54-5 (S)-2-[(2-Chloro-benzyl)-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-propionic acid 
• 351527-04-3 (S)-2-[(3,5-Dichloro-2-hydroxy-benzenesulfonyl)-(2-nitro-benzyl)-amino]-propionic acid 
• 145980-64-9 2-acetoxy-3,5-dichlorobenzenesulfonyl chloride 
• 159895-60-0 3-(3,5-Dichloro-2-hydroxybenzenesulfonamido)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol 
• 35337-99-6 3,5-dichloro-2-hydroxy-benzenesulphonamide 
• 1416767-48-0 1,3-dichloro-10,10-dibenzyl-8,9,10,10a-tetrahydro-7H-pyrido[1,2-b][4,1,2]benzoxathiazine 5,5-dioxide 

Relevant academic research and scientific papers

WDR5-MYC INHIBITORS

Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

As neuroprotective agents of pharmaceutical compounds

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.

Enantioselective addition of diethylzinc to benzaldehyde catalyzed by chiral titanate complexes with helical ligands

Enantioselective alkylation of benzaldehyde with Et2Zn has been studied. This reaction is catalyzed by helical titanium complexes of tetradentate ligands and has been found to give good to excellent enantioselectivities.

Chlorosulfonation of Some Aromatic Compounds

Dibenzylideneacetone, biphenyl, o-toluanilide, 5-chlorosalicylic acid, and 2,4-, 2,5- and 3,5-dichlorophenol have been reacted with chlorosulfonic acid and the sulfonyl chlorides thus obtained have been characterized by reaction with nucleophilic reagents; in the case of the dichlorophenols the orientation has been confirmed by PMR spectroscopy.The results of preliminary antibacterial and fungicidal screening are included.