23384-33-0Relevant academic research and scientific papers
Diamination of Domino Aryne Precursor with Sulfonamides
Qiu, Dachuan,He, Jia,Yue, Xiao,Shi, Jiarong,Li, Yang
supporting information, p. 3130 - 3133 (2016/07/14)
The reaction of a domino aryne precursor with sulfonamides efficiently afforded both 1,3-diaminobenzenes and trisubstituted 1,3-diaminobenzenes by simply varying the reaction conditions. Mechanistic study supports the sequential formation of two transient aryne intermediates involved in the reaction.
Pro-Neurogenic Compounds
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Paragraph 0276-0278, (2014/03/24)
Compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death are disclosed herein. In vivo activity tests suggest that th
Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent
Naidoo, Jacinth,Bemben, Christopher J.,Allwein, Shawn R.,Liang, Jue,Pieper, Andrew A.,Ready, Joseph M.
supporting information, p. 4429 - 4431 (2013/07/26)
A scalable synthesis of the neuroprotective agent P7C3-A20 is described. The synthesis has provided hundred-gram batches of the final compound for biological evaluation in rodents primates. The synthesis can be performed without chromatographic purificati
