2339-58-4

Basic information

• Product Name: 3-Fluoro-5-methoxyaniline
• Synonyms: 3-Fluoro-5-methoxyaniline 98%;3-Amino-5-fluoroanisole;3-Fluoro-5-Methoxy-phenylaMine;3-Amino-5-fluoroanisole, 5-Fluoro-m-anisidine;Benzenamine, 3-fluoro-5-methoxy-
• CAS NO: 2339-58-4
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.14
• Mol File: 2339-58-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 226.2°C at 760 mmHg
• Flash Point: 90.6°C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 0.0831mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Refrigerated.
• PKA: 3.16±0.10(Predicted)
• CAS DataBase Reference: 3-Fluoro-5-methoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-5-methoxyaniline(2339-58-4)
• EPA Substance Registry System: 3-Fluoro-5-methoxyaniline(2339-58-4)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 2339-58-4(Hazardous Substances Data)

Usage

General Description

3-Fluoro-5-methoxyaniline, also known as 5-methoxy-3-fluoroaniline, is a chemical compound with the molecular formula C7H8FNO. It is an aniline derivative with a fluorine atom attached to the third carbon and a methoxy group attached to the fifth carbon of the aromatic ring. 3-Fluoro-5-methoxyaniline is commonly used in organic synthesis and pharmaceutical research due to its potential as a building block in the production of various pharmaceutical compounds. It is also used as a precursor in the manufacture of dyes and pigments. Additionally, 3-Fluoro-5-methoxyaniline has been studied for its potential biological and pharmacological activities, including its role as a potential antitumor and antibacterial agent. However, its specific mechanisms of action and potential applications in medicine are still being researched.

InChI:InChI=1/C7H8FNO/c1-10-7-3-5(8)2-6(9)4-7/h2-4H,9H2,1H3

Upstream product

• 29578-39-0 1-bromo-3-fluoro-5-methoxybenzene 
• 2265-94-3 1,3-difluoro-5-nitrobenzene 
• 202925-08-4 1-chloro-3-fluoro-5-methoxybenzene 
• 7087-60-7 1-fluoro-3-methoxy-5-nitrobenzene 
• 7440-66-6 zinc 

Downstream Products

• 1352622-33-3 C₁₆H₁₀FN₃O 
• 1333950-17-6 C₂₃H₁₆FN₅O 
• 1167056-58-7 1-fluoro-3-iodo-5-methoxybenzene 
• 939771-60-5 3-fluoro-5-iodophenol 
• 1333950-33-6 C₉H₆FNO 
• 29578-41-4 5-Fluor-3-methoxy-α-hydroximino-propiophenon 
• 36699-70-4 1-(5-Fluor-3-methoxyphenyl)-1-propanol 
• 1167055-92-6 3-amino-5-fluorophenol 

Relevant articles and documents

Oxalic amide ligands, and uses thereof in copper-catalyzed coupling reaction of aryl halides

The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C—N, C—O and C—S bonds.

Assembly of Primary (Hetero)Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia

A general and practical catalytic system for aryl amination of aryl chlorides with aqueous or gaseous ammonia has been developed, with CuI as the catalyst and bisaryl oxalic diamides as the ligands. The reaction proceeds at 105-120°C to provide a diverse set of primary (hetero)aryl amines in high yields with various functional groups.

An examination of the palladium/Mor-DalPhos catalyst system in the context of selective ammonia monoarylation at room temperature

An examination of the [{Pd(cinnamyl)Cl}2]/Mor-DalPhos (Mor-DalPhos=di(1-adamantyl)-2-morpholinophenylphosphine) catalyst system in Buchwald-Hartwig aminations employing ammonia was conducted to better understand the catalyst formation process and to guide the development of precatalysts for otherwise challenging room-temperature ammonia monoarylations. The combination of [{Pd(cinnamyl)Cl}2] and Mor-DalPhos afforded [(κ 2-P,N-Mor-DalPhos)Pd(η1-cinnamyl)Cl] (2), which, in the presence of a base and chlorobenzene, generated [(κ2-P,N- Mor-DalPhos)Pd(Ph)Cl] (1 a). Halide abstraction from 1 a afforded [(κ3-P,N,O-Mor-DalPhos)Pd(Ph)]OTf (5), bringing to light a potential stabilizing interaction that is offered by Mor-DalPhos. An examination of [(κ2-P,N-Mor-DalPhos)Pd(aryl)Cl] (1 b-f) and related precatalysts for the coupling of ammonia and chlorobenzene at room temperature established the suitability of 1 a in such challenging applications. The scope of reactivity for the use of 1 a (5 mol %) encompassed a range of (hetero)aryl (pseudo)halides (X=Cl, Br, I, OTs) with diverse substituents (alkyl, aryl, ether, thioether, ketone, amine, fluoro, trifluoromethyl, and nitrile), including chemoselective arylations. Copyright