3-Fluoro-5-methoxyaniline

Base Information

• Chemical Name: 3-Fluoro-5-methoxyaniline
• CAS No.: 2339-58-4
• Molecular Formula: C7H8FNO
• Molecular Weight: 141.145
• Hs Code.: 2922299090
• Mol file: 2339-58-4.mol

Synonyms:3-Amino-5-fluoroanisole;5-fluoro-3-methoxy-aniline;5-Fluor-3-methoxy-anilin;3-Amino-5-fluoranisol;3-fluoro-5-methoxybenzenamine;3-fluoro-5-methoxyphenylamine;3-fluoranyl-5-methoxy-aniline;

Chemical Property of 3-Fluoro-5-methoxyaniline

Chemical Property:

• Vapor Pressure: 0.0831mmHg at 25°C
• Boiling Point: 226.2oC at 760 mmHg
• PKA: 3.16±0.10(Predicted)
• Flash Point: 90.6oC
• PSA: 35.25000
• Density: 1.176g/cm3
• LogP: 1.99770
• Storage Temp.: Refrigerated.

Purity/Quality:

97% ^*data from raw suppliers

3-Fluoro-5-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-5-methoxyaniline

There total 6 articles about 3-Fluoro-5-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-fluoro-3-methoxy-5-nitrobenzene (7087-60-7) → 3-fluoro-5-methoxyphenylamine (2339-58-4)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 75 ℃; for 6h;

DOI:10.1021/ja2058583

Reference yield: 80.0%

1-chloro-3-fluoro-5-methoxybenzene (202925-08-4) → 3-fluoro-5-methoxyphenylamine (2339-58-4)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; ammonia; sodium t-butanolate; In 1,4-dioxane; at 50 ℃; for 16h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/anie.201000526

Reference yield: 80.0%

→ 3-fluoro-5-methoxyphenylamine (2339-58-4)

Guidance literature:

upstream raw materials:

1-fluoro-3-methoxy-5-nitrobenzene

zinc

1-chloro-3-fluoro-5-methoxybenzene

1,3-difluoro-5-nitrobenzene

Downstream raw materials:

C₁₆H₁₀FN₃O

C₂₃H₁₆FN₅O

1-fluoro-3-iodo-5-methoxybenzene

3-fluoro-5-iodophenol