23399-77-1

Usage

Chemical Properties

CLEAR SLIGHTLY BROWN TO BROWN LIQUID AFTER MELTING

InChI:InChI=1/C7H3ClF3I/c8-4-1-2-6(12)5(3-4)7(9,10)11/h1-3H

Upstream product

• 445-03-4 4-chloro-2-(trifluoromethyl)aniline 

Downstream Products

• 320-41-2 4-chloro-2-(trifluoromethyl)benzonitrile 
• 142994-09-0 4-chloro-2-(trifluoromethyl)benzoic acid 
• 618885-83-9 2-(4-chloro-2-trifluoromethyl-phenyl)-ethanol 
• 601513-31-9 2-(4-chloro-2-(trifluoromethyl)phenyl)acetic acid 
• 1587727-74-9 tert-butyl {(2S,3S)-6-[4-chloro-2-(trifluoromethyl)phenyl]-3-hydroxyhex-5-yn-2-yl}carbamate 
• 1104382-86-6 methyl 3-[4-chloro-2-(trifluoromethyl)phenyl]propanoate 
• 916420-46-7 3-[4-chloro-2-(trifluoromethyl)phenyl]propanoic acid 
• 1219454-01-9 3-[4-(2-trifluoromethyl-4-chlorophenyl)pyridin-2-yl]-1,2,4-oxadiazol-5-one 
• 1219454-39-3 4-(2-trifluoromethyl-4-chlorophenyl)pyridine-2-carboxamide oxime 
• 1219454-38-2 4-(2-trifluoromethyl-4-chlorophenyl)pyridine-2-carbonitrile 
• 1219454-37-1 4-(2-trifluoromethyl-4-chlorophenyl)pyridine-N-oxide 
• 1214324-15-8 4-(2-trifluoromethyl-4-chlorophenyl)pyridine 

Relevant academic research and scientific papers

Single C?F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group

The transformation of a single C?F bond of trifluoromethylarenes bearing a hydrosilyl group at the ortho position was achieved. The activation of the hydrosilyl group with a trityl cation in the presence of nucleophiles allowed for selective C?F bond func

TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS

The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthama, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases. (I)