320-41-2

Usage

Chemical Properties

Yellow liquid

InChI:InChI=1/C8H3ClF3N/c9-6-2-1-5(4-13)7(3-6)8(10,11)12/h1-3H

Upstream product

• 108-20-3 di-isopropyl ether 
• 23399-77-1 4-chloro-2-trifluoromethyliodobenzene 
• 557-21-1 dicyanozinc 
• 623-03-0 4-Cyanochlorobenzene 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 320-42-3 4-hydroxy-2-(trifluoromethyl)benzonitrile 
• 142994-09-0 4-chloro-2-(trifluoromethyl)benzoic acid 
• 115591-65-6 methyl 4-chloro-2-(trifluoromethyl)benzoate 
• 320-43-4 4-chloro-2-(trifluoromethyl)benzaldehyde 
• 143782-20-1 4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile 
• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 

Relevant academic research and scientific papers

Silver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent

Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in other contexts and could potentially be extended to other trifluoromethylation reactions. (Chemical Equation Presented).

1-(HETERO)ARYL-3-AMINO-PYROLLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS

The present invention relates to compounds of the Formula (I) which are useful for treating conditions associated with mGluR3 receptors, such as depression, schizophrenia and migraine, pharmaceutical compositions thereof, and methods of using the same.

Phenylimidazolidine preparation process

A subject of the invention is a preparation process for the products of formula (I): STR1 in which R1 and R2 represent in particular hydrogen, cyano, halogen or amino,R3 represents in particular hydrogen or hydroxyl alkyl, R4 and R5 represent in particular optionally substituted alkyl, X and y represent oxygen or sulphur, characterized in that a product of formula (A): STR2 is prepared in which W represents a halogen atom or a hydantoin derivative, which is subjected to various reactions in order to obtain the products of formula (I), all their isomers and their salts.