234-77-5

Basic information

• Product Name: tetrazolo[1,5-c]quinazoline
• Synonyms: {Tetrazolo[1,5-c]quinazoline}; Tetraazolo(1,5-c)quinazoline; Tetraazolo[1,5-c]quinazoline; Tetrazolo(1,5-c)quinazoline
• CAS NO: 234-77-5
• Molecular Formula: C₈H₅N₅
• Molecular Weight: 171.1588
• Mol File: 234-77-5.mol
• Article Data: 3

Chemical Properties

• Density: 1.62g/cm³
• Refractive Index: 1.871
• CAS DataBase Reference: tetrazolo[1,5-c]quinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: tetrazolo[1,5-c]quinazoline(234-77-5)
• EPA Substance Registry System: tetrazolo[1,5-c]quinazoline(234-77-5)

Safety Data

• Hazardous Substances Data: 234-77-5(Hazardous Substances Data)

Upstream product

• 118-92-3 anthranilic acid 
• 77287-34-4 formamide 
• 36075-44-2 4-hydrazinoquinazoline 
• 491-36-1 4-Hydroxyquinazoline 

Downstream Products

• 1286712-20-6 2-isocyanophenylcarbodiimide 
• 31892-42-9 N-cyanoanthranilonitrile 
• 31892-41-8 N-cyano-benzimidazole 
• 18216-38-1 5-(2-aminophenyl)tetrazole 

Relevant articles and documents

Convergent Three-Component Tetrazole Synthesis

A microwave-accelerated, simple, and efficient method for the construction of the 1,5-tetrazole scaffold was developed. It comprises a multicomponent reaction of an amine, a carboxylic acid derivative, and an azide source. On the basis of the availability of the archetypical starting materials, this method provided very versatile synthetic access to 1,5-disubstituted tetrazoles. The usefulness of this method was demonstrated in the synthesis of biologically important fused tetrazole scaffolds and the marketed drug cilostazol.

The scope and mechanism of phosphonium-mediated SNAr reactions in heterocyclic amides and ureas

(Chemical Equation Presented) An efficient "one-step" synthesis of cyclic amidines and guanidines has been developed. Treatment of cyclic amides and ureas with benzotriazol-l-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), base, and nitrogen nucleophiles leads to the formation of the corresponding cyclic amidines and guanidines, typically in good to excellent yields. This method has also been used to prepare heteroaryl ethers and thioethers using phenol and thiophenol nucleophiles. Time course NMR and HPLC-MS studies have facilitated explicit characterization of the proposed intermediates (the phosphonium salt and HOBt adduct); the data reveal a stepwise reaction pathway.