234-82-2

Usage

Chemical Properties

Pale Yellow Solid

Uses

Different sources of media describe the Uses of 234-82-2 differently. You can refer to the following data:
1. Shows hypotensive action
2. Shows hypotensive action.

InChI:InChI=1/C8H5N5/c1-2-4-7-6(3-1)5-9-13-8(7)10-11-12-13/h1-5H

Upstream product

• 1044569-46-1 1-hydrazinophthalazine 
• 16015-46-6 1(2H)-phthalazinethione 
• 119-67-5 o-carboxybenzaldehyde 

Downstream Products

• 15171-44-5 Cyanophenyl carbene 
• 317333-42-9 C₈H₅N 
• 420848-43-7 C₈H₅N 

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Synthesis and positive inotropic evaluation of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties09/29/2019

Four series of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties were synthesized and evaluated for their positive inotropic activity by measuring the left atrium stroke volume in isolated rabbit-heart preparations. Several comp...detailed

Solid-phase synthesis of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives09/28/2019

A general method is reported for the solid-phase synthesis of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives based on the cyclization of resin-bound chlorophthalazines 4 with various hydrazides or sodium azide. The resin-bound chlorophthalazines 4, produced by nucl...detailed

Relevant academic research and scientific papers

Convergent Three-Component Tetrazole Synthesis

A microwave-accelerated, simple, and efficient method for the construction of the 1,5-tetrazole scaffold was developed. It comprises a multicomponent reaction of an amine, a carboxylic acid derivative, and an azide source. On the basis of the availability of the archetypical starting materials, this method provided very versatile synthetic access to 1,5-disubstituted tetrazoles. The usefulness of this method was demonstrated in the synthesis of biologically important fused tetrazole scaffolds and the marketed drug cilostazol.

SYNTHESIS OF 1,5-SUBSTITUTED TETRAZOLES FROM SECONDARY THIOAMIDES

A new, rather simple method for the conversion of thiamides and similar structures into 1,5-substituted tetrazoles is described.The procedure employs TMS-N3 and mild Lewis acid, like SnCl4 in an inert solvent at room temperature and leads to high yields.Such compounds are of increasing interest for their pharmaceutical properties.