234080-62-7

Upstream product

• 100-53-8 phenylmethanethiol 
• 167159-67-3 2-<6-(3,4-dimethoxyphenyl)-6-hydroxy-1-oxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline 
• 1071-71-2 ethyl 6-chloro-6-oxohexanoate 
• 167159-65-1 ethyl 6-(3,4-dimethoxy-(E)-oxobenzene)hexanoate 
• 38767-74-7 6-(3,4-dimethoxy-(E)-oxobenzene)hexanoic acid 
• 91-16-7 1,2-dimethoxybenzene 
• 167159-66-2 2-<6-(3,4-dimethoxyphenyl)-1,6-dioxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline 

Relevant academic research and scientific papers

Novel multidrug resistance reversal agents

A series of 59 α-aryl-α-thioether-alkyl, -alkanenitrile, and - alkanecarboxylic acid methyl ester tetrahydroisoquinoline and isoindoline derivatives (15a-48) were synthesized and evaluated as multidrug resistance (MDR) reversal agents. The compounds were

MDR reversal agents

Compounds of the general formula: STR1 wherein R1, R2, R3, R4 and R5 are herein described, A is a straight or branched (C2 -C12)alkyl or a phenyl moiety and B is a moiety of the formula: STR2 The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.