234081-72-2

Upstream product

• 52221-07-5 6-(tert-butoxy)-6-oxohexanoic acid 
• 234081-53-9 (S)-2-Amino-N-((S)-1,2-bis-hexadecylcarbamoyl-ethyl)-succinamic acid benzyl ester 
• 143-27-1 hexadecylamine 
• 124-04-9 Adipic acid 
• 234081-51-7 N-(1,2-bis-hexadecylcarbamoyl-ethyl)-2-tert-butoxycarbonylamino-succinamic acid benzyl ester 
• 229467-48-5 (1,2-bis-hexadecylcarbamoyl-ethyl)-carbamic acid tert-butyl ester 
• 229467-49-6 2-amino-N¹,N⁴-dihexadecyl-succinamide 

Downstream Products

• 234081-82-4 5-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-pentanoic acid 

Relevant academic research and scientific papers

Trigger lipids inducing pH-dependent liposome fusion

Aspartic acid-derived artificial lipids (ADLs; s indicates the number of the methylene groups, s=2, 4, 6, 8, 10, 12) (Scheme 1) with various carboxyl alkyl chains as head groups are designed and synthesized, which are incorporated into liposome membranes by sonication. Fluorescence resonance energy transfer (FRET) measurements indicate that ADL6, ADL8 and ADL10 have high lipid-mixing ability in the acidic solution. The other ADLs, however, do not induce remarkable liposome fusion at acidic nor neutral pH. The hydrophobicity of the head groups of ADL6, ADL8 and ADL10 is suitable as triggers of membrane fusion.

Non-peptidic liposome-fusion compounds at acidic pH

Liposomes including aspartic acid-derived artificial lipids (ADL) with various carboxy alkyl chains as head groups (ADLn; n indicates the number of the methylene groups, n = 2,4,6,8,10,12) are prepared, in which ADL6 and ADL8 liposomes induce remarkably high lipid-mixing in the acidic region.