52221-07-5Relevant academic research and scientific papers
PANTETHEINE DERIVATIVES AND USES THEREOF
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, (2020/06/19)
The present disclosure relates to compounds of Formula (I), (II), or (II'): (I), (II), (II'), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.
QUINAZOLINONE-TYPE COMPOUNDS AS CRTH2 ANTAGONISTS
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, (2012/05/04)
This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH2 receptor.
Trigger lipids inducing pH-dependent liposome fusion
Ogawa, Yoshikatsu,Kodaka, Masato,Okuno, Hiroaki
, p. 51 - 68 (2007/10/03)
Aspartic acid-derived artificial lipids (ADLs; s indicates the number of the methylene groups, s=2, 4, 6, 8, 10, 12) (Scheme 1) with various carboxyl alkyl chains as head groups are designed and synthesized, which are incorporated into liposome membranes by sonication. Fluorescence resonance energy transfer (FRET) measurements indicate that ADL6, ADL8 and ADL10 have high lipid-mixing ability in the acidic solution. The other ADLs, however, do not induce remarkable liposome fusion at acidic nor neutral pH. The hydrophobicity of the head groups of ADL6, ADL8 and ADL10 is suitable as triggers of membrane fusion.
Process for preparation of dicarboxylic acid monoesters
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, (2008/06/13)
A process for producing a dicarboxylic acid monoester which comprises subjecting a dicarboxylic acid monoester or an alkali metal salt of a dicarboxylic acid monoester and a metal alkoxide to transesterification in the presence of an organic solvent, or a process for producing a dicarboxylic acid monoester which comprises subjecting a dicarboxylic acid monoester or an alkali metal salt of a dicarboxylic acid monoester and an alcohol to transesterification in the presence of a metal alkoxide.
Alpha-and beta-substituted trifluoromethyl ketones as phospholipase inhibitors
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, (2008/06/13)
Inhibitors of the cytosolic phospholipase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, R1, R2, R3, R4, Raand Rbare as defined in the specification.
Alpha-and beta- substituted trifluoromethyl ketones as phospholipase inhibitors
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, (2008/06/13)
Inhibitors of the cytosolic phospholipase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, R1, R2, R3, R4, Ra and Rb are as defined in the specification.
Non-peptidic liposome-fusion compounds at acidic pH
Ogawa, Yoshikatsu,Tomohiro, Takenori,Yamazaki, Yoshimitsu,Kodaka, Masato,Okuno, Hiroaki
, p. 823 - 824 (2007/10/03)
Liposomes including aspartic acid-derived artificial lipids (ADL) with various carboxy alkyl chains as head groups (ADLn; n indicates the number of the methylene groups, n = 2,4,6,8,10,12) are prepared, in which ADL6 and ADL8 liposomes induce remarkably high lipid-mixing in the acidic region.
