23429-92-7

Upstream product

• 136-95-8 2-amino-benzthiazole 
• 626-34-6 ethyl aminocrotonate 
• 141-97-9 ethyl acetoacetate 
• 626-34-6 ethyl 3-aminobut-2-enoate 
• 463-51-4 Ketene 
• 439688-61-6 N'-(benzothiazol-2-yl)-N,N-dimethylacetamidine 
• 2235-46-3 N,N-diethyl-3-oxobutanamide 
• 105-45-3 acetoacetic acid methyl ester 

Relevant academic research and scientific papers

Reagent-controlled regiodivergent intermolecular cyclization of 2-aminobenzothiazoles with β-ketoesters and β-ketoamides

Two regiodivergent approaches to intermolecular cyclization of 2-aminobenzothiazoles with β-ketoesters and amides have been developed, controlled by the reagents employed. With the Br?nsted base KOt-Bu and CBrCl3 as radical initiator, benzo[d]imidazo[2,1-b]thiazoles are synthesized via attack at the α-carbon and keto carbon of the β-ketoester moiety. In contrast, switching to the Lewis acid catalyst, In(OTf)3, results in the regioselective nucleophilic attack at both carbonyl groups forming benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ones instead.

Multicomponent reaction-based discovery of pyrimido[2,1-b][1,3]benzothiazole (PBT) as a novel core for full-color-tunable AIEgens

The Hf(OTf)4-catalyzed three-component reaction (3CR) was employed as a powerful tool for facile access to a library of 23 pyrimido[2,1-b][1,3]benzothiazole (PBT)-based AIEgens with full-color tunability, solid-state fluorescence quantum yields

MRGX Receptor Antagonists

The invention relates to a method for preventing or treating a disease or disorder that is associated with the MrgX2 receptor. The invention also relates to MrgX2 antagonists and physiologically acceptable salts thereof. The invention also relates to pharmaceutical compositions and dosage forms comprising an MrgX2 antagonist.

FUSED PYRIMIDINEONE COMPOUNDS AS TRPV3 MODULATORS

The present invention provides transient receptor potential vanilloid (TRPV) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are pro

Efficient regioselective synthesis of triheterocyclic compounds: Imidazo[2,1-b]benzothiazoles, pyrimido[2,1-b]benzothiazolones and pyrimido[2,1-b]benzothiazoles

The preparation and characterisation of triheterocyclic compounds, via annulation reactions, are described. Amidines 1 reacted with substituted bromomethyl compounds, acid chlorides, and acrylic dienophiles to afford the corresponding imidazo[2,1-b]benzot

ETUDE COMPARATIVE DE LA REACTIVITE DE COMPOSES β-DICARBONYLES ET DES ANALOGUES ENAMINOCARBONYLES VIS-A-VIS D'AMINES HETEROCYCLIQUES

Reactions between five β-dicarbonyl compounds (1-5) or their enaminocarbonyl analogues (6-10) and three heterocyclic amines (12-14) are studied.The two types of carbonyl derivatives give rise to the formation of the same final products.Kinetic data are es