23429-92-7

Basic information

• Product Name: 2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one
• Synonyms: 2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one
• CAS NO: 23429-92-7
• Molecular Formula: C11H8N2OS
• Molecular Weight: 216.25902
• Mol File: 23429-92-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one(23429-92-7)
• EPA Substance Registry System: 2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one(23429-92-7)

Safety Data

• Hazardous Substances Data: 23429-92-7(Hazardous Substances Data)

Upstream product

• 136-95-8 2-amino-benzthiazole 
• 626-34-6 ethyl aminocrotonate 
• 141-97-9 ethyl acetoacetate 
• 626-34-6 ethyl 3-aminobut-2-enoate 
• 463-51-4 Ketene 
• 439688-61-6 N'-(benzothiazol-2-yl)-N,N-dimethylacetamidine 
• 105-45-3 acetoacetic acid methyl ester 
• 2235-46-3 N,N-diethyl-3-oxobutanamide 

Relevant articles and documents

Reagent-controlled regiodivergent intermolecular cyclization of 2-aminobenzothiazoles with β-ketoesters and β-ketoamides

Two regiodivergent approaches to intermolecular cyclization of 2-aminobenzothiazoles with β-ketoesters and amides have been developed, controlled by the reagents employed. With the Br?nsted base KOt-Bu and CBrCl3 as radical initiator, benzo[d]imidazo[2,1-b]thiazoles are synthesized via attack at the α-carbon and keto carbon of the β-ketoester moiety. In contrast, switching to the Lewis acid catalyst, In(OTf)3, results in the regioselective nucleophilic attack at both carbonyl groups forming benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ones instead.

MRGX Receptor Antagonists

The invention relates to a method for preventing or treating a disease or disorder that is associated with the MrgX2 receptor. The invention also relates to MrgX2 antagonists and physiologically acceptable salts thereof. The invention also relates to pharmaceutical compositions and dosage forms comprising an MrgX2 antagonist.

Efficient regioselective synthesis of triheterocyclic compounds: Imidazo[2,1-b]benzothiazoles, pyrimido[2,1-b]benzothiazolones and pyrimido[2,1-b]benzothiazoles

The preparation and characterisation of triheterocyclic compounds, via annulation reactions, are described. Amidines 1 reacted with substituted bromomethyl compounds, acid chlorides, and acrylic dienophiles to afford the corresponding imidazo[2,1-b]benzot