2343-30-8

Usage

Chemical structure

1-fluoro-4-(2-fluoroethyl)benzene consists of a benzene ring with a fluorine atom at the 1 position and a 2-fluoroethyl group at the 4 position.

Classification

It is classified as a fluorinated aromatic compound.

Pharmaceutical synthesis

It is commonly used as a building block in the synthesis of pharmaceuticals.

Agrochemical synthesis

It is also used in the synthesis of agrochemicals.

Medicinal chemistry

It has potential applications in the field of medicinal chemistry due to its ability to modify the reactivity and pharmacological properties of biologically active molecules.

Specialty polymers and materials

It can be used in the production of specialty polymers and materials due to its unique fluorinated structure.

Safety

It is important to handle 1-fluoro-4-(2-fluoroethyl)benzene with caution as fluorinated compounds can be harmful if not properly managed.

Upstream product

• 1743-00-6 4-fluoro-β,β-difluorostyrene 
• 7589-27-7 2-(4-Fluorophenyl)ethanol 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 
• 878376-35-3 pyridine-2-sulfonyl fluoride 
• 84030-20-6 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine 
• 375-72-4 Nonafluorobutanesulfonyl fluoride 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 113399-22-7 1-(1-Chloro-2-fluoro-ethyl)-4-fluoro-benzene 
• 405-99-2 para-fluorostyrene 

Relevant academic research and scientific papers

Rapid Deoxyfluorination of Alcohols with N-Tosyl-4-chlorobenzenesulfonimidoyl Fluoride (SulfoxFluor) at Room Temperature

The deoxyfluorination of alcohols is a fundamentally important approach to access alkyl fluorides, and thus the development of shelf-stable, easy-to-handle, fluorine-economical, and highly selective deoxyfluorination reagents is highly desired. This work describes the development of a crystalline compound, N-tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor), as a novel deoxyfluorination reagent that possesses all of the aforementioned merits, which is rare in the arena of deoxyfluorination. Endowed by the multi-dimensional modulating ability of the sulfonimidoyl group, SulfoxFluor is superior to 2-pyridinesulfonyl fluoride (PyFluor) in fluorination rate, and is also superior to perfluorobutanesulfonyl fluoride (PBSF) in fluorine-economy. Its reaction with alcohols not only tolerates a wide range of functionalities including the more sterically hindered alcoholic hydroxyl groups, but also exhibits high fluorination/elimination selectivity. Because SulfoxFluor can be easily prepared from inexpensive materials and can be safely handled without special techniques, it promises to serve as a practical deoxyfluorination reagent for the synthesis of various alkyl fluorides.

Copper-Catalyzed Regioselective Hydroalkylation of 1,3-Dienes with Alkyl Fluorides and Grignard Reagents

Copper complexes generated in situ from CuCl2, alkyl Grignard reagents, and 1,3-dienes play important roles as catalytic active species for the 1,2-hydroalkylation of 1,3-dienes by alkyl fluorides through C-F bond cleavage. The alkyl group is introduced to an internal carbon atom of the 1,3-diene regioselectively, thus giving rise to the branched terminal alkene product. Making the switch: A copper-hydride species, generated by the treatment of a copper salt with alkyl Grignard reagents, catalyzes the 1,2-hydroalkylation of 1,3-dienes by alkyl fluorides and Grignard reagents. The alkyl group of the alkyl fluoride is selectively introduced to an internal carbon atom of the 1,3-diene and the Grignard reagent acts as hydride source to give the branched terminal alkene, even in the presence of alkenes and alkynes.