2343-30-8

Basic information

• Product Name: 1-fluoro-4-(2-fluoroethyl)benzene
• CAS NO: 2343-30-8
• Molecular Formula: C₈H₈F₂
• Molecular Weight: 142.1459
• Mol File: 2343-30-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 163.1°C at 760 mmHg
• Flash Point: 40.4°C
• Density: 1.077g/cm³
• Vapor Pressure: 2.75mmHg at 25°C
• Refractive Index: 1.457
• CAS DataBase Reference: 1-fluoro-4-(2-fluoroethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluoro-4-(2-fluoroethyl)benzene(2343-30-8)
• EPA Substance Registry System: 1-fluoro-4-(2-fluoroethyl)benzene(2343-30-8)

Safety Data

• Hazardous Substances Data: 2343-30-8(Hazardous Substances Data)

Usage

Chemical structure

1-fluoro-4-(2-fluoroethyl)benzene consists of a benzene ring with a fluorine atom at the 1 position and a 2-fluoroethyl group at the 4 position.

Classification

It is classified as a fluorinated aromatic compound.

Pharmaceutical synthesis

It is commonly used as a building block in the synthesis of pharmaceuticals.

Agrochemical synthesis

It is also used in the synthesis of agrochemicals.

Medicinal chemistry

It has potential applications in the field of medicinal chemistry due to its ability to modify the reactivity and pharmacological properties of biologically active molecules.

Specialty polymers and materials

It can be used in the production of specialty polymers and materials due to its unique fluorinated structure.

Safety

It is important to handle this compound with caution as fluorinated compounds can be harmful if not properly managed.

Upstream product

• 7589-27-7 2-(4-Fluorophenyl)ethanol 
• 375-72-4 Nonafluorobutanesulfonyl fluoride 
• 84030-20-6 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine 
• 878376-35-3 pyridine-2-sulfonyl fluoride 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 
• 459-57-4 4-fluorobenzaldehyde 
• 1743-00-6 4-fluoro-β,β-difluorostyrene 

Downstream Products

• 405-99-2 para-fluorostyrene 
• 113399-22-7 1-(1-Chloro-2-fluoro-ethyl)-4-fluoro-benzene 

Relevant articles and documents

Rapid Deoxyfluorination of Alcohols with N-Tosyl-4-chlorobenzenesulfonimidoyl Fluoride (SulfoxFluor) at Room Temperature

The deoxyfluorination of alcohols is a fundamentally important approach to access alkyl fluorides, and thus the development of shelf-stable, easy-to-handle, fluorine-economical, and highly selective deoxyfluorination reagents is highly desired. This work describes the development of a crystalline compound, N-tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor), as a novel deoxyfluorination reagent that possesses all of the aforementioned merits, which is rare in the arena of deoxyfluorination. Endowed by the multi-dimensional modulating ability of the sulfonimidoyl group, SulfoxFluor is superior to 2-pyridinesulfonyl fluoride (PyFluor) in fluorination rate, and is also superior to perfluorobutanesulfonyl fluoride (PBSF) in fluorine-economy. Its reaction with alcohols not only tolerates a wide range of functionalities including the more sterically hindered alcoholic hydroxyl groups, but also exhibits high fluorination/elimination selectivity. Because SulfoxFluor can be easily prepared from inexpensive materials and can be safely handled without special techniques, it promises to serve as a practical deoxyfluorination reagent for the synthesis of various alkyl fluorides.