23443-10-9 Usage
Uses
Used in Pharmaceutical Industry:
Pyrido[1,2-a]pyrimidin-4-one is utilized as a key component in drug development for its diverse biological activities. It serves as a foundation for creating new medications targeting various health conditions due to its anti-inflammatory, anti-tumor, and anti-bacterial properties.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, Pyrido[1,2-a]pyrimidin-4-one is employed as a scaffold for designing and synthesizing new compounds with improved pharmacological profiles. Its structural attributes allow for modifications that can enhance the efficacy and selectivity of drugs, contributing to the advancement of personalized medicine.
Used in Drug Discovery:
Pyrido[1,2-a]pyrimidin-4-one is leveraged in drug discovery processes to identify lead compounds with therapeutic potential. Its presence in natural sources and demonstrated biological activities make it an attractive candidate for high-throughput screening and further optimization to treat a spectrum of diseases.
Used in Natural Product Chemistry:
As a naturally occurring compound, Pyrido[1,2-a]pyrimidin-4-one is used in the study of natural product chemistry to understand its biosynthetic pathways and ecological roles. This knowledge can inform the development of sustainable methods for its production and application in medicine.
Each application underscores the versatility and significance of Pyrido[1,2-a]pyrimidin-4-one in the realm of pharmaceuticals and medicine, highlighting its multifaceted utility in addressing contemporary health challenges.
Check Digit Verification of cas no
The CAS Registry Mumber 23443-10-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,4,4 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 23443-10:
(7*2)+(6*3)+(5*4)+(4*4)+(3*3)+(2*1)+(1*0)=79
79 % 10 = 9
So 23443-10-9 is a valid CAS Registry Number.
23443-10-9Relevant academic research and scientific papers
Suzuki-Miyaura cross-coupling reactions of halo derivatives of 4H-pyrido[1,2-a]pyrimidin-4-ones
Molnar, Annamaria,Kapros, Anita,Parkanyi, Laszlo,Mucsi, Zoltan,Vlad, Gabor,Hermecz, Istvan
supporting information; experimental part, p. 6559 - 6565 (2011/11/05)
The palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of halo derivatives of 4H-pyrido[1,2-a]pyrimidin-4-one with (het)arylboronic acids allow easy access to (het)aryl and vinyl derivatives of this bicycle in good to excellent yields, even from chloro derivatives. The sequence of reactivity of the halogen in the different positions of the ring system was also investigated. 6-Phenyl-4H-pyrido[1,2-a]pyrimidin-4-one could be prepared by thermal cyclization of isopropylidene (6-phenylpyrid-2-ylamino)methylenemalonate, together with a small amount of 7-phenyl-1,4-dihydro-1,8-naphthyridin-4-one.
