23445-16-1

Basic information

• Product Name: (5R,6S)-6-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol
• CAS NO: 23445-16-1
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.2429
• Mol File: 23445-16-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 331.5°C at 760 mmHg
• Flash Point: 154.3°C
• Density: 1.117g/cm³
• Vapor Pressure: 6.2E-05mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: (5R,6S)-6-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (5R,6S)-6-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol(23445-16-1)
• EPA Substance Registry System: (5R,6S)-6-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol(23445-16-1)

Safety Data

• Hazardous Substances Data: 23445-16-1(Hazardous Substances Data)

Upstream product

• 21413-70-7 8,9-dihydro-7H-benzocycloheptene-5,6-dione 6-oxime 
• 23417-11-0 6-Amino-6,7,8,9-tetrahydro-benzocyclohepten-5-one; hydrochloride 
• 450368-19-1 6-Amino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol 

Relevant articles and documents

Chemo- and stereoselective synthesis of benzocycloheptene and 1-benzoxepin derivatives as α-sympathomimetic and anorexigenic agents

The synthesis and pharmacological evaluation of cis- and trans-6-amino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ols 4a-c and 5a-c and cis- and trans-4-amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ols 4d-f and 5d-f were carried out. Chemo- and stereoselective synthesis of 5a-f was achieved by reduction of corresponding α-amino ketones 3a-f with LiAl(t-BuO) 3H. cis-4-Amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol 4d and trans-4-amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol 5d exhibited marked anorexigenic activity in mice at a dose of LD50 800 and 500mg/kg and ED50 75 and 55mg/kg, respectively, while the analog cis-2,3-dihydroxy-6-amino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol 8 showed typical α-sympathomimetic activity.