23456-82-8

Usage

Uses

Used in Pharmaceutical Synthesis:
4-ethoxy-1H-indole is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with improved therapeutic profiles.
Used in Agrochemical Production:
In the agrochemical industry, 4-ethoxy-1H-indole is utilized as a precursor in the creation of compounds that can enhance crop protection and management.
Used in Organic Synthesis:
4-ethoxy-1H-indole is employed as a building block in organic synthesis, facilitating the construction of complex organic molecules for a range of applications.
Used in Anti-inflammatory Applications:
4-ethoxy-1H-indole is used as an anti-inflammatory agent, leveraging its biological activity to reduce inflammation and associated symptoms.
Used in Antifungal Applications:
4-ethoxy-1H-indole is utilized as an antifungal agent, helping to combat fungal infections due to its inherent antifungal properties.
Used in Anticancer Research:
4-ethoxy-1H-indole is explored in anticancer research as a potential therapeutic agent, with its ability to target and inhibit cancer cell growth and proliferation.
Used in Therapeutic Development:
4-ethoxy-1H-indole is of interest for its potential in therapeutic development, particularly in the areas of inflammation, fungal infections, and cancer treatment, due to its demonstrated biological activities.

InChI:InChI=1/C10H11NO/c1-2-12-10-5-3-4-9-8(10)6-7-11-9/h3-7,11H,2H2,1H3

Upstream product

• 2380-94-1 1H-indol-4-ol 
• 90734-98-8 4-ethoxyindole-3-carbaldehyde 
• 487-89-8 Indole-3-carboxaldehyde 
• 75-03-6 ethyl iodide 

Downstream Products

• 220657-59-0 4-ethoxy-1-methoxy-2-phenylindole 
• 90734-98-8 4-ethoxyindole-3-carbaldehyde 
• 220657-56-7 2,3-dihydro-4-ethoxyindole 

Relevant academic research and scientific papers

INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS

The present invention discloses and claims a series of substituted indolyl-piperidinyl benzylamines of formula (I), wherein R1, R2 and R3 are as described herein. More specifically, the compounds of this invention are inhibitors of β-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted indolyl-piperidinyl benzylamines. In one of the embodiments, there is provided the compounds of formula (I) wherein R3 is (II).

1,2,3-Thiadiazole substituted pyrazolones as potent KDR/VEGFR-2 kinase inhibitors

KDR kinase inhibition is considered to play an important role in regulating angiogenesis, which is vital for the survival and proliferation of tumor cells. Recently we disclosed a structure-based kinase inhibitor design strategy which led to the identification of a new class of VEGFR-2/KDR kinase inhibitors bearing heterocyclic substituted pyrazolones as the core template. Instability in a rat S9 preparation and poor iv PK profiles for most of these inhibitors necessitated exploration of new pyrazolones to identify new analogs with improved metabolic stability. Optimization of the heterocyclic moiety led to the identification of the thiadiazole series of pyrazolones (D) as potent VEGFR-2/KDR kinase inhibitors. SAR modifications, kinase selectivity profiling, and structural elements for improved PK properties were explored. Oral bioavailability up to 29% was achieved in the rat. Modeling results based on the Glide XP docking approach supported our postulation regarding the interaction of the lactam segment of the pyrazolones with the hinge region of the KDR kinase.

Antiviral indoleoxoacetyl piperazine derivatives

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

Photo-induced rearrangement of 1-ethoxy-2-phenylindole

Photoirradiation of 1-ethoxy-2-phenylindole in methanol afforded 3- and 6-ethoxy-2-phenylindoles. The structural determination of the latter is carried out by direct comparison of its spectral data with those of the authentic 4-, 5-, 6-, and 7-ethoxy-2-phenylindoles, whose syntheses are also included.