23461-59-8Relevant academic research and scientific papers
Acid-Catalyzed Intramolecular Imination / Nucleophilic Trapping of 4-Aminobutanal Derivatives: One-Pot Access to 2-(Pyrazolyl)pyrrolidines
Smolobochkin, Andrey V.,Rizbayeva, Tanzilya S.,Gazizov, Almir S.,Voronina, Julia K.,Dobrynin, Alexey B.,Gildebrant, Anastasiya V.,Strelnik, Anna G.,Sazykin, Ivan S.,Burilov, Alexander R.,Pudovik, Michail A.,Sazykina, Marina A.
, p. 5709 - 5719 (2019)
A first successful synthesis of 2-(pyrazolyl)pyrrolidines is reported starting from readily available reagents. A wide variety of N-substituted 2-(pyrazolyl)pyrrolidines are obtained with up to 96 % yield. The influence of the obtained compounds on biofilm formation by V. aquamarinus DSM 26054 and A. calcoaceticus VKPM B–10353 have been studied. Some of the tested compounds were found to suppress the growth of bacterial biofilms at nanomolar concentrations and thus are promising candidates for further studies.
