56430-08-1

Usage

Uses

A metabolite of the antipyrine analgesic drug Phenazone.

InChI:InChI=1/C12H14N2O/c1-9-4-6-11(7-5-9)14-12(15)8-10(2)13(14)3/h4-8H,1-3H3

Upstream product

• 35496-19-6 3-methyl-1-(4'-methylphenyl)-5-pyrazolone 
• 74-88-4 methyl iodide 
• 141-97-9 ethyl acetoacetate 
• 539-44-6 N-4-methylphenylhydrazine 
• 86-92-0 3-methyl-1-(4-methylphenyl)-2-pyrazolin-5-one 
• 74-83-9 methyl bromide 

Downstream Products

• 875232-48-7 1,5-dimethyl-2-p-tolyl-4-(2,2,2-trichloro-1-hydroxy-ethyl)-1,2-dihydro-pyrazol-3-one 
• 153839-94-2 chloro(2,3-dimethyl-1-(4'-methylphenyl)-3-pyrazoline-5-one)(o-hydroxyacetophenonato)mercury(II) 
• 23461-59-8 2-Ethoxy-1-(p-acetamidophenylsulfonyl)-pyrrolidin 

Relevant academic research and scientific papers

SCREENING METHODS AND THERAPEUTIC APPLICATIONS BASED ON BACTERIAL MOTILITY INHIBITION

The present invention relates to compounds for use in treating and/or preventing a bacterial infection or a condition associated with the bacterial infection, wherein the bacterial infection is caused by flagellated bacteria. The present invention further relates to a method of identifying compounds having bacterial anti-motility activity.

Pd(ii)-Catalyzed alkyne annulation through allylic isomerization: synthesis of spiro-cyclopentadiene pyrazolones

The Pd(ii)-catalyzed activation of Csp2-H bond and double alkyne annulation which proceedsviaallylic isomerization is reported for the first time. This reaction of antipyrines with alkynes provides an efficient synthetic route for the biologically important spiro-cyclopentadiene pyrazolones. In the presence of Lawesson's reagent, this Pd(ii)-catalyzed annulation reaction affords another spiro-cyclopentadiene pyrazolone which displays very good fluorescence properties.

The selective condensation of pyrazolones to isatins in aqueous medium

The selective condensation of pyrazolones with isatins using water as the reaction medium is presented. This strategy provides an environmentally benign synthetic route to synthesize various potentially bioactive pyrazolone substituted oxindoles.

Copper-catalyzed acylation of pyrazolones with aldehydes to afford 4-acylpyrazolones

Copper-catalyzed direct acylation of the alkenyl C-H bond in 1,2-dihydro-3H-pyrazol-3-ones has been developed, affording a series of 4-acylpyrazolones in moderate to good yields. Notably, this protocol involves readily accessible substrates and reagents, which have good functional group tolerance leading to pyrazolone derivatives under mild reaction conditions.

Room-temperature direct alkenylation of 5-pyrazolones

A mild and efficient method for the direct alkenylation of 5-pyrazoles by Pd-catalyzed C-H bond activation is described. The reaction smoothly proceeds at room temperature to provide products in up to 92 % yield. Heterocycles containing the 5-pyrazolone moiety are synthesized by an oxidative Heck-type reaction. The direct alkenylation of 5-pyrazolones at room temperature through Pd-catalyzed C-H bond activation is described. Copyright

An easy direct arylation of 5-pyrazolones

A mild, efficient and catalytic ligand-free method for the direct arylation of 5-pyrazolones by Pd-catalyzed C-H bond activation is reported. The process smoothly proceeds and yields are moderate to excellent.