23474-61-5

Usage

General Description

2-amino-10-ethyldibenzo[b,f][1,4]oxazepin-11(10H)-one is a chemical compound with the molecular formula C17H16N2O2. It belongs to the class of compounds known as dibenzazepines, which are tricyclic compounds containing a dibenzazepine moiety, which is a seven-membered ring with the two benzene rings connected via a nitrogen. The compound is a white to off-white solid that is insoluble in water but soluble in organic solvents. It has potential pharmacological properties and is used in the development of novel drugs for the treatment of certain medical conditions.

Upstream product

• 140412-87-9 10-Ethyl-2-nitro-10H-dibenzo[b,f][1,4]oxazepin-11-one 
• 16398-16-6 2-nitro-10H-dibenzo1,4-oxazepin-11-one 
• 16398-07-5 2-chloro-N-(2-hydroxyphenyl)-5-nitrobenzamide 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 

Relevant academic research and scientific papers

Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2. Tricyclic Pyridobenzoxazepinones and Dibenzoxazepinones

Dibenzoxazepin-11(10H)-ones (III), pyridobenzoxazepin-6(5H)-ones (IV), and pyridobenzoxazepin-5(6H)-ones (V) were found to inhibit human immunodeficiency virus type 1 reverse transcriptase with IC50 values as 19 nM.A-ring substitution has a profound effect on activity, with appropriate substituents at the positions ortho and para to the lactam nitrogen providing dramatically enhanced potency.Substitution in the C-ring is generally neutral or detrimental to activity.Although a C-ring amino substituent at the position meta to the lactam carbonyl is generally beneficial to activity, it has essentially no effect when the A-ring is optimally substituted.Like the dipyridodiazepinone nevirapine, compounds III-V are specific for HIV-1 RT, exhibiting no inhibitory activity against HIV-2 RT or other virial reverse transcriptase enzymes.