234751-30-5

Upstream product

• 30418-59-8 3-Aminophenylboronic acid 
• 27631-29-4 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one 
• 1119772-98-3 N-{3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}acetamide 
• 1119772-78-9 N-[3-(2-chloro-6,7-dimethoxyquinazolin-4-yl)phenyl]formamide 
• 74-89-5 methylamine 
• 947620-70-4 3-(2-chloro-6,7-dimethoxy-quinazolin-4-yl)-phenylamine 
• 234751-27-0 6,7-dimethoxy-2-methylamino-4-(3-nitrophenyl)quinazoline 

Downstream Products

• 947620-48-6 methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate 
• 234751-64-5 4-(3-benzylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline 
• 234751-40-7 4-[3-(4-chlorobenzoylamino)phenyl]-6,7-dimethoxy-2-methylaminoquinazoline 
• 234751-45-2 4-(3-cyclopropanoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline 
• 234751-62-3 4-(3-benzenesulfonamidephenyl)-6,7-dimethoxy-2-methylaminoquinazoline 
• 234751-46-3 4-[3-(3-cyclopentyloxy-4-methoxybenzoylamino)phenyl]-6,7-dimethoxy-2-methylaminoquinazoline 
• 234751-50-9 4-[3-(3-benzyloxybenzoylamino)phenyl]-6,7-dimethoxy-2-methylaminoquinazoline 
• 234751-52-1 4-[3-(2-benzyloxybenzoylamino)phenyl]-6,7-dimethoxy-2-methylaminoquinazoline 
• 234751-47-4 6,7-dimethoxy-4-methylamino-4-[3-(3,4,5-trimethoxybenzoylamino)phenyl]quinazoline 
• 234751-54-3 6,7-dimethoxy-2-methylamino-4-[3-(4-methylthiobenzoylamino)phenyl]quinazoline 
• 234751-69-0 6,7-dimethoxy-2-methylamino-4-[3-(1-pyrrolyl)phenyl]quinazoline 
• 234751-44-1 4-[3-(3,4-dichlorobenzoylamino)phenyl]-6,7-dimethoxy-2-methylaminoquinazoline 
• 234751-33-8 6,7-dimethoxy-2-methylamino-4-[3-(2-pyridinecarbonylamino)phenyl]quinazoline 
• 234751-38-3 4-[3-(2-chlorobenzoylamino)phenyl]-6,7-dimethoxy-2-methylaminoquinazoline 

Relevant academic research and scientific papers

METHOD FOR PRODUCING QUINAZOLINE DERIVATIVE

[4-(3-aminophenyl)-6,7-dimethoxyquinazolin-2-yl]methylamine with a favorable yield and high purity can be produced by subjecting a compound represented by the following formula (I) to a step of reacting with methylamine and a step of deprotection if desired: wherein L represents a protective group of amino.

NOVEL PREPARATION FOR EXTERNAL USE

A compound represented by the formula (I), salt thereof, or hydrate thereof has an excellent anti-pruritic effect and an excellent effect in terms of metabolism. The topical formulation of the present invention has excellent skin absorption properties of the compound represented by the formula (I), salt thereof, or hydrate thereof. Furthermore, the topical formulation of the present invention is excellent in stability because ingredients are hardly bled after long-term storage. wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl.

4-(3-BENZOYLAMINOPHENYL)-6,7-DIMETHOXY-2- METHYLAMINOQUINAZOLINE DERIVATIVE

A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl.

4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives

A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl.

Nitrogenous heterocyclic derivatives and medicine thereof

The present invention provides a novel nitrogen-containing heterocyclic compound useful as a phosphodiesterase-4 inhibitor, and a medicament comprising the same. Further, the present invention provides a nitrogen-containing heterocyclic compound represented by the following formula, its salt or hydrates thereof, and a medicament comprising the same. wherein the ring A is an aromatic hydrocarbon ring which may have a heteroatom, the ring B represents (a) a saturated hydrocarbon ring, (b) an unsaturated hydrocarbon ring, (c) a saturated heterocyclic ring or (d) an unsaturated heterocyclic ring, all of which may have a substituent group.