23476-81-5Relevant academic research and scientific papers
Oxidative Cyclization Approach to Benzimidazole Libraries
Arnold, Eric P.,Mondal, Prolay K.,Schmitt, Daniel C.
supporting information, p. 1 - 5 (2020/02/20)
An efficient approach to the parallel synthesis of benzimidazoles from anilines is described. Library approaches to vary the N1 and C2 vectors of benzimidazoles are well established; however, C4-C7 variation has traditionally relied on 1,2-dianiline build
Method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions
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Paragraph 0018; 0057, (2019/01/21)
The invention discloses a method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions. According to the method, glacial aceticacid is taken as a catalyst; at solvent-free room temperature conditions, physical grinding is adopted, reaction of 2-substituted arylamines (2-mercapto arylamine, 2-aminophenol, and o-phenylenediamine) and aromatic aldehydes is carried out using physical grinding. The method is friendly to the environment, is simple in operation, is safe, is low in cost, and is high in efficiency. Compared withthe prior art, the advantages are that: the method is suitable for a large amount of functional groups, yield is high, less by-product is generated, operation is simple, the method is safe, cost is low, and the method is friendly to the environment.
An efficient route for the synthesis of benzimidazoles via a hydrogen-transfer strategy between o-nitroanilines and alcohols
Li, Xiaotong,Hu, Renhe,Tong, Yao,Pan, Qiang,Miao, Dazhuang,Han, Shiqing
supporting information, p. 4645 - 4649 (2016/09/23)
[1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) has been used as an efficient catalyst for the synthesis of 2-substituted benzimidazoles via a hydrogen-transfer strategy. Various 2-substituted benzimidazoles were synthesized in good to excellent yields (up to 97%). The reaction shows good functional group tolerance. And no additional additive, oxidant, or reductant was required for the reaction.
Catalyst-free one-pot synthesis of benzimidazoles from 1,2-diaminoarenes and alcohols
Marri, Mahender Reddy,Peraka, Swamy,Macharla, Arun Kumar,Mameda, Naresh,Kodumuri, Srujana,Nama, Narender
supporting information, p. 6520 - 6525 (2015/01/08)
A new and efficient protocol is described for the one-pot synthesis of benzimidazoles from a variety of aryl alcohols and 1,2-diaminoarenes. The yields were ranging from moderate to excellent. Moreover, the present method is utilizing alcohols instead of aldehydes and the reactions are carried out under solvent- and catalyst-free conditions, offering an environmentally benign process.
Indium-mediated one-pot benzimidazole synthesis from 2-nitroanilines or 1,2-dinitroarenes with orthoesters
Kim, Jaeho,Kim, Jihye,Lee, Hyunseung,Lee, Byung Min,Kim, Byeong Hyo
experimental part, p. 8027 - 8033 (2011/11/06)
One-pot reduction-triggered heterocyclizations from 2-nitroanilines or 1,2-dinitroarenes to benzimidazoles were investigated in this study. In the presence of indium/AcOH in ethyl acetate at reflux, reaction of 2-nitroanilines or 1,2-dinitroarenes with R-C(OMe)3 (R=Me, Ph) produced excellent yields of the corresponding benzimidazoles within 30 min to 6 h depending on the substituents of the starting materials. Indium-mediated heterocyclization of 2-nitroanilines to benzimidazole was faster and had better yields than 1,2-dinitroarenes to benzimidazole under similar reaction conditions.
Substituted 2,5'-bi-1H-benzimidazoles: Topoisomerase I inhibition and cytotoxicity
Jung Sun Kim,Gatto,Yu,Liu,Liu,LaVoie
, p. 992 - 998 (2007/10/03)
Several 2'-aryl-5-substituted-2,5'-bi-1H-benzimidazole derivatives were synthesized and evaluated as topoisomerase I poisons and for their cytotoxicity toward the human lymphoblast cell line RPMI 8402. This study focused on 18 2,5'-bi-1H-benzimidazole der
2--5(6)-BENZIMIDAZOLECARBOXAMIDES
Sklyarova, I. V.,Garabadzhiu, A. V.,Ginzburg, O. F.
, p. 337 - 341 (2007/10/02)
Condensation of the dihydrochlorides of 2-methoxyethyl carboximidates with o-phenylenediamines gave the amides of bisbenzimidazolecarboxylic acids containing amino or carboxyl groups in the amide fragment.The obtained a
