234768-80-0

Upstream product

• 4380-88-5 2-butylacrylic acid 
• 534-59-8 n-butylmalonic acid 
• 3282-30-2 pivaloyl chloride 
• 223906-39-6 N-Benzyl-5,5-dimethyloxazolidin-2-one 
• 168297-85-6 (S)-4-benzyl-5,5-dimethyloxazolidin-2-one 

Downstream Products

• 234768-81-1 4S-benzyl-3-[2-(benzyloxyamino-methyl)-hexanoyl]-5,5-dimethyl-oxazolidin-2-one 

Relevant academic research and scientific papers

ANTIBACTERIAL AGENTS

Selected compounds of formula (I) are antibacterial agents: formula (I) wherein R2 represents a substituted or unsubstituted C1-C6 alkyl, cycloalkyl (C1-C6 alkyl)- or aryl (C1-C6 /SUB

Antibacterial agents

Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R1 represents hydrogen, C1-C6 alkyl or C1-C6 alkyl substituted by one or more halogen atoms, or, except when Q is a radical of the formula: —N(OH)CH(═O), a hydroxy, C1-C6 alkoxy, C1-C4 alkenyloxy, amino, C1-C4 alkylamino, or di-(C1-C6 alkyl)amino group; R2 represents a substituted or unsubstituted C1-C6 alkyl, cycloalkyl(C1-C6 alkyl)- or aryl(C1-C6 alkyl)-group; and A represents a group of formula (IIA), or (IIB) wherein R4 represents the side chain of a natural or non-natural alpha amino acid, and R5 and R6 when taken together with the nitrogen atom to which they are attached form a saturated heterocyclic first ring of 5 to 7 atoms as specified in the description.

Antibacterial agents

Compounds of formula (I) are antibacterial agents wherein: R3and R4, taken together with the carbon atoms to which they are respectively attached, form an optionally substituted saturated carbocyclic or heterocyclic ring of 5 to 16 a

Antibacterial agents

A method for the treatment of bacterial infections in humans and non-human mammals, which comprises administering to a subject suffering such infection an antibacterially effective dose of a compound of formula (I) or a pharmaceutically or veterinarily ac

N-formyl hydroxylamine derivatives as antibacterial agents

Compounds of formula (I) are in the preparation of antibacterial agents, wherein: R1represents hydrogen, C1-C6alkyl or C1-C6alkyl substituted by one or more halogen atoms; R2represents a group R10(X)n—(ALK)— wherein R10represents hydrogen, a C1-C6alkyl, C2-C6alkenyl, C1-C6alkynyl, cycloalkyl, aryl, or heterocyclyl group, any of which may be unsubstituted or substituted by (C1-C6)alkyl, (C1-C6)alkoyy, hydroxy, mercapto, (C1-C6)alkylthio, amino, halo, trifluoromethyl, cyano, nitro, —COOH, —CONH2, —COORA, —NHCORA, —CONHRA, —NHRA, —NRARB, or —CONRARBwherein RAand RBare independently a (C1-C6)alkyl group, and ALK represents a straight or branched divalent C1-C6alkylene, C2-C6alkenylene, or C2-C6alkynylene radical, which may be interrupted by one or more non-adjacent —NH—, —O— or —S— linkages, X represents —NH—, —O— or —S—, and n is 0 or 1, R represents hydrogen or C1-C6alkyl, R3represents the characterising group or a natural or non-natural α amino acid in which any functional groups may be protected; and R4represents an ester or thioester group.

Cytostatic agents

Compounds of formula (I) wherein R4 is an ester or thioester group and R, R1, R2 and R3 are as defined in the specification, inhibit proliferation of tumor cells.

Asymmetric synthesis of BB-3497 - A potent peptide deformylase inhibitor

By screening a library of metalloenzyme inhibitors, the N-formyl-hydroxylamine derivative BB-3497 was identified as a potent inhibitor of Escherichia coli peptide deformylase with antibacterial activity both in vitro and in vivo. The homochiral synthesis of BB-3497, involving a novel asymmetric Michael addition reaction is described.