23478-16-2Relevant academic research and scientific papers
MULTI-FLUORESCENT SUBSTANCE INCLUDING NOVEL COUMARIN DERIVATIVE, AND LED LIGHT SOURCE-BASED MICROFLUORESCENT QUANTITATIVE BIOSENSOR FOR DIAGNOSIS USING SAME
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Page/Page column, (2014/12/09)
The present invention relates to a novel coumarin derivative, to a method for preparing the same, and a multi-fluorescent substance that includes a plurality of the coumarin derivatives and is able to emit light using an LED light source. A novel coumarin derivative multi-fluorescent substance according to the present invention has an optimal emission wavelength band of 512 nm to 590 nm and thereby is effective in improving a signal intensity and stability since light emission using an LED light source is possible. In addition, higher fluorescence reactivity is exhibited compared to coumarin fluorescent substances known in the related arts since one molecule has a plurality of fluorescent substances, and the problem of the coumarin fluorescent substance possibly binding to a binding site of the antigen of the antibody is solved since fluorescence detection is possible even when a minimum number of fluorescent substance molecules bind to an antibody. Moreover, the novel coumarin derivative multi-fluorescent substance according to the present invention is suitably used in a fluorescent-linked immunosorbent assay (FLISA) and a rapid fluorescent immunochromatographic test (FICT) as an LED-based microfluorescent quantitative biosensor for diagnosis, therefore, diseases such as malaria may be rapidly and quantitatively analyzed.
Pd/C-catalyzed reductive mono-N-alkylation of nitrophenol derivatives in one-pot way
Jin, Zhonghao,Li, Dao,Wang, Xingyi,Lu, Guanzhong
experimental part, p. 16 - 20 (2010/09/07)
A range of different nitrophenol derivatives were converted in one-pot to the corresponding secondary alkyl aminophenols in good to excellent yields by using ketones as alkyl source and hydrogen over 10 wt% Pd/C as reducing agent. In all examples, except for one, the secondary amine was the sole alkylation product isolated. When aldehydes were used as alkyl source, the corresponding tertiary amine as a sole alkylation product was isolated.
