235-25-6

Upstream product

• 91-22-5 quinoline 
• 139032-23-8 1-isocyano-4-(trifluoromethyl)benzene 
• 1613-37-2 Quinoline N-oxide 
• 4648-54-8 trimethylsilylazide 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 16136-52-0 4-cyanoindole 
• 3759-28-2 (2-cyanophenyl)acetonitrile 
• 1224886-29-6 2-(4-(p-tolyl)-1H-1,2,3-triazol-1-yl)quinoline 
• 1224886-28-5 2-(4-phenyl-1H-1,2,3-triazol-1-yl)quinoline 
• 1224886-30-9 2-(4-(cyclohex-1-en-1-yl)-1H-1,2,3-triazol-1-yl)quinoline 
• 75266-12-5 1,3-diazabenzo[d]cyclohepta-1,2,4,6-tetraene 
• 288-94-8 1H-tetrazole 
• 88012-11-7 N-Chinol-2-yl-iminotriphenyl-phosphoran 

Relevant academic research and scientific papers

Reaction of N-fluoropyridinium fluoride with isonitriles and TMSN 3: A convenient one-pot synthesis of tetrazol-5-yl pyridines

Reaction of N-fluoropyridinium fluoride generated in situ with a series of isonitriles and TMSN3 led to the formation of the corresponding tetrazol-5-yl pyridines in good yields (37-84%). A similar reaction sequence for quinoline yielded the respective derivatives of 2-quinoline. The proposed reaction mechanism involves the intermediate formation of a highly reactive carbene species.

Reaction of Trimethylsilyl Azide with C=N-O Bond

Trimethylsilyl azide (TMSA) was reacted with an oxime ester or a Reissert salt in the presence of trimethylsilyl trifluoromethanesulfonate to give tetrazole derivative.The details of these reactions are examined.