2350-60-9

Upstream product

• 124-40-3 dimethyl amine 
• 255842-10-5 2,6-Dichloro-4-nitrophenyl isocyanide 
• 70106-94-4 N-(2,6-dichloro-4-nitrophenyl)formamide 
• 68-12-2 N,N-dimethyl-formamide 
• 99-30-9 4-nitro-2,6-dichloroaniline 

Downstream Products

• 84562-32-3 N'-(2,6-Dichloro-4-{[1-(3-fluoro-phenyl)-meth-(E)-ylidene]-amino}-phenyl)-N,N-dimethyl-formamidine 
• 84562-33-4 N'-(2,6-Dichloro-4-{[1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-phenyl)-N,N-dimethyl-formamidine 
• 85103-55-5 N²-<2,6-dichloro-4-<(3-fluoro-4-methoxybenzyl)amino>phenyl>-N¹,N¹-dimethylformamidine 
• 84562-30-1 N²-<2,6-dichloro-4-<(3-fluoro-4-methoxybenzylidene)amino>phenyl>-N¹,N¹-dimethylformamidine 
• 84562-34-5 N'-(2,6-Dichloro-4-{[1-(3-trifluoromethyl-phenyl)-meth-(E)-ylidene]-amino}-phenyl)-N,N-dimethyl-formamidine 
• 84562-31-2 N²-(4-amino-2,6-dichlorophenyl)-N¹,N¹-dimethylformamidine 

Relevant academic research and scientific papers

Synthesis and reactions of aromatic and heterocyclic isocyanides

Reactions of halo-and nitroanilines with dichlorocarbene resulted in formation of the corresponding isocyanides in poor yields. Better results are obtained by treatment with phosphoryl chloride of formanilides having the same substituents. The latter procedure was used to prepare previously inaccessible derivatives of 2-pyridyl, 2-thiazolyl, and 1,3,4-thiadiazol-2-yl isocyanides. To prevent polymerization, the isocyanides were isolated as complexes with copper(I) bromide which can be decomposed with aqueous potassium cyanide to release free isocyanides. Aryl and heteryl isocyanides reacted with such nucleophiles as water and dimethylamine under mild conditions.

N2-(4-Substituted-2,6-dichlorophenyl)-N1,N1-dimethylformamidines as Antihypertensive and Diuretic Agents

The synthesis of a series of N2--2,6-dichlorophenyl>-N1,N1-dimethylformamidines that caused marked blood pressure lowering and/or diuresis in spontaneously hypertensive rats (SHR) is reported.Diuretic activity was not always associated with acute antihypertensive activity.Central nervous system effects, most notably sedation, were observed.Compound 9d, which lowered arterial blood pressure 37 mmHg in SHR when dosed at 100 mg/kg, was further evaluated in chronic hypertensive dogs because of apparent minimal CNS effects.A reduction in arterial blood pressure of 32 mmHg at 1.0 mg/kg during a 6-h postdosing interval was observed.This response was unrelated to α- or β-adrenergic blockade, angiotensin I antagonism, or neuronal or ganglionic blockade.CNS effects were also observed.