2350-99-4

Basic information

• Product Name: P-TOLYLAMINO-ACETIC ACID HYDRAZIDE
• Synonyms: 2-(4-methylanilino)acetohydrazide;2-[(4-methylphenyl)amino]ethanehydrazide;2-[(4-methylphenyl)amino]acetohydrazide (non-preferred name)
• CAS NO: 2350-99-4
• Molecular Formula: C₉H₁₃N₃O
• Molecular Weight: 179.22
• Mol File: 2350-99-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 432.5°Cat760mmHg
• Flash Point: 215.4°C
• Appearance: /
• Density: 1.184g/cm³
• Vapor Pressure: 1.1E-07mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: P-TOLYLAMINO-ACETIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: P-TOLYLAMINO-ACETIC ACID HYDRAZIDE(2350-99-4)
• EPA Substance Registry System: P-TOLYLAMINO-ACETIC ACID HYDRAZIDE(2350-99-4)

Safety Data

• Hazardous Substances Data: 2350-99-4(Hazardous Substances Data)

Usage

General Description

P-TOLYLAMINO-ACETIC ACID HYDRAZIDE is a chemical compound with the molecular formula C9H13N3O2. It is commonly used as a precursor in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and organic pigments. P-TOLYLAMINO-ACETIC ACID HYDRAZIDE has also been studied for its potential use in the treatment of epilepsy and other neurological disorders. P-TOLYLAMINO-ACETIC ACID HYDRAZIDE is considered to be a moderately hazardous substance and should be handled and stored according to proper safety protocols and guidelines.

InChI:InChI=1/C9H13N3O/c1-7-2-4-8(5-3-7)11-6-9(13)12-10/h2-5,11H,6,10H2,1H3,(H,12,13)

Upstream product

• 21911-68-2 ethyl 2-(p-tolylamino)acetate 
• 106-49-0 p-toluidine 
• 21911-69-3 N-(p-tolyl)glycine 

Downstream Products

• 142787-64-2 C₁₀H₁₂N₃OS₂^(1-)*K⁽¹⁺⁾ 
• 79476-57-6 4-methylphenylaminoacetoisatin hydrazone 
• 1242157-76-1 2-(p-toluidino)-N'-(3-oxo-1,3-diphenylpropylidene)acetohydrazide 
• 329915-94-8 N'-(thiophen-2-yl-methylene)-2-(p-tolylamino)acetohydrazide 
• 339167-90-7 N'-(furan-2-yl-methylene)-2-(p-tolylamino)acetohydrazide 

Relevant articles and documents

Synthesis, α-glucosidase inhibition, and molecular docking studies of novel N-substituted hydrazide derivatives of atranorin as antidiabetic agents

A series of novel N-substituted hydrazide derivatives were synthesized by reacting atranorin, a compound with a natural depside structure (1), with a range of hydrazines. The natural product and 12 new analogues (2–13) were investigated for inhibition of α-glucosidase. The N-substituted hydrazide derivatives showed more potent inhibition than the original. The experimental results were confirmed by docking analysis. This study suggests that these compounds are promising molecules for diabetes therapy. Molecular dynamics simulations were carried out with compound 2 demonstrating the best docking model using Gromac during simulation up to 20 ns to explore the stability of the complex ligand-protein. Furthermore, the activity of all synthetic compounds 2–13 against a normal cell line HEK293, used for assessing their cytotoxicity, was evaluated.

Synthesis and characterization of some bi, tri and tetravalent transition metal complexes of N′-(furan-2-yl-methylene)-2-(p-tolylamino) acetohydrazide HL1 and N′-(thiophen-2-yl-methylene)-2-(p- tolylamino)acetohydrazide HL2

The tetradentate Schiff bases hydrazone ligands HL1, HL 2 and their metal complexes have been prepared and characterized by analytical, spectral (IR, UV-vis, 1H NMR and ESR), molar conductivity, magnetic and TGA measurements. The results show that all the metal complexes are non-electrolytes, except (2, 10 and 20) which have ionic nature. The ligands coordinate in keto-neutral form and act as bidentate or tridentate for all metal complexes, except complexes (4 and 12). The ligands react as monobasic tetradentate and tridentate for complexes (4 and 12), respectively. Octahedral/tetrahedral Co(II) and Ni(II), octahedral/square planar Cu(II), and octahedral Mn(II), Fe(III), Cr(III), Ru(III), Hf(IV) and Zr(IV)O geometries were proposed. The ESR spectra of copper complexes (12 and 14) indicate d( x2-y2) ground state with covalent bond character. The thermal decomposition and the types of crystallized water for some metal complexes were studied. The studied metal complexes are very weakly active against the tested microorganisms.

Synthesis of substituted oxadiazoles, thiadiazoles and triazoles and evaluation of their biological activity

-