2350-99-4

Usage

Uses

Used in Pharmaceutical Industry:
P-TOLYLAMINO-ACETIC ACID HYDRAZIDE is used as a precursor in the synthesis of pharmaceuticals for its ability to be chemically modified and incorporated into various drug molecules.
Used in Agrochemical Industry:
P-TOLYLAMINO-ACETIC ACID HYDRAZIDE is used as a precursor in the synthesis of agrochemicals, contributing to the development of pesticides and other agricultural products.
Used in Dye and Pigment Industry:
P-TOLYLAMINO-ACETIC ACID HYDRAZIDE is used in the production of dyes and organic pigments due to its chemical properties that can be utilized to create a range of colors and compounds.
Used in Neurological Disorder Treatment Research:
P-TOLYLAMINO-ACETIC ACID HYDRAZIDE is used in research for its potential application in the treatment of epilepsy and other neurological disorders, as it may have properties that can be harnessed for therapeutic purposes.

InChI:InChI=1/C9H13N3O/c1-7-2-4-8(5-3-7)11-6-9(13)12-10/h2-5,11H,6,10H2,1H3,(H,12,13)

Upstream product

• 21911-68-2 ethyl 2-(p-tolylamino)acetate 
• 21911-69-3 N-(p-tolyl)glycine 
• 106-49-0 p-toluidine 

Downstream Products

• 92515-98-5 4-phenyl-1-(N-p-tolylamino)acetyl thiosemicarbazide 
• 680594-42-7 [4-phenyl-5-(N-p-tolylamino)methyl-1,2,4-triazol-3-yl]thioglycolylhydrazide 
• 482652-40-4 ethyl [4-phenyl-5-(N-p-tolylamino)methyl-1,2,4-triazol-3-yl]thioglycolate 
• 162693-64-3 5-N-(4-tolyl)aminomethyl-3H-1,3,4-oxadiazole-2-thione 
• 339167-90-7 N'-(furan-2-yl-methylene)-2-(p-tolylamino)acetohydrazide 
• 329915-94-8 N'-(thiophen-2-yl-methylene)-2-(p-tolylamino)acetohydrazide 
• 142787-64-2 C₁₀H₁₂N₃OS₂^(1-)*K⁽¹⁺⁾ 

Relevant academic research and scientific papers

Synthesis, α-glucosidase inhibition, and molecular docking studies of novel N-substituted hydrazide derivatives of atranorin as antidiabetic agents

A series of novel N-substituted hydrazide derivatives were synthesized by reacting atranorin, a compound with a natural depside structure (1), with a range of hydrazines. The natural product and 12 new analogues (2–13) were investigated for inhibition of α-glucosidase. The N-substituted hydrazide derivatives showed more potent inhibition than the original. The experimental results were confirmed by docking analysis. This study suggests that these compounds are promising molecules for diabetes therapy. Molecular dynamics simulations were carried out with compound 2 demonstrating the best docking model using Gromac during simulation up to 20 ns to explore the stability of the complex ligand-protein. Furthermore, the activity of all synthetic compounds 2–13 against a normal cell line HEK293, used for assessing their cytotoxicity, was evaluated.

Synthesis and biological potentials of some new 1,3,4-oxadiazole analogues

In continuation of our research to explore new antiproliferative agents, we report herein the synthesis and antiproliferative activity of two new series of N-(substituted phenyl)-5-aryl-1,3,4-oxadiazol-2-amine (4a–j) and N-{[5-aryl-1,3,4-oxadiazol-2-yl]me

Synthesis and characterization of some bi, tri and tetravalent transition metal complexes of N′-(furan-2-yl-methylene)-2-(p-tolylamino) acetohydrazide HL1 and N′-(thiophen-2-yl-methylene)-2-(p- tolylamino)acetohydrazide HL2

The tetradentate Schiff bases hydrazone ligands HL1, HL 2 and their metal complexes have been prepared and characterized by analytical, spectral (IR, UV-vis, 1H NMR and ESR), molar conductivity, magnetic and TGA measurements. The results show that all the metal complexes are non-electrolytes, except (2, 10 and 20) which have ionic nature. The ligands coordinate in keto-neutral form and act as bidentate or tridentate for all metal complexes, except complexes (4 and 12). The ligands react as monobasic tetradentate and tridentate for complexes (4 and 12), respectively. Octahedral/tetrahedral Co(II) and Ni(II), octahedral/square planar Cu(II), and octahedral Mn(II), Fe(III), Cr(III), Ru(III), Hf(IV) and Zr(IV)O geometries were proposed. The ESR spectra of copper complexes (12 and 14) indicate d( x2-y2) ground state with covalent bond character. The thermal decomposition and the types of crystallized water for some metal complexes were studied. The studied metal complexes are very weakly active against the tested microorganisms.

Synthesis, spectral studies and biological activities of some N-bridged heterocycles derived from 3-arylaminomethyl-4-amino-5-mercapto-1,2,4- triazoles

Synthesis of four 3-arylaminomethyl-4-amino-5-mercapto-1,2,4-triazoles starting from substituted anilines is described. These triazoles were employed in the synthesis of some N-bridged heterocycles carrying arylaminomethyl substituents. All the newly synthesized compounds were characterized by analytical, NMR and mass spectral studies. Some of the newly synthesized compounds were screened for their antibacterial and antiviral properties.