235094-15-2

Upstream product

• 814-68-6 acryloyl chloride 
• 235094-10-7 (2S,4aS,7R,8aR)-4,4,7-Trimethyl-2-((S)-1-phenylselanyl-ethyl)-octahydro-benzo[e][1,3]oxazine 
• 84782-51-4 α-phenylselenenyl propionaldehyde 
• 34837-55-3 Phenylselenyl bromide 

Downstream Products

• 235094-33-4 (3'S,4'S)-8-(3',4'-dimethylpyrrolidinyl)-menthol 
• 235094-31-2 8-(3',4'-cis-dimethylpyrrolidinyl)-menthol 
• 235094-29-8 (3'R,4'R)-8-(3',4'-dimethylpyrrolidinyl)-menthol 

Relevant academic research and scientific papers

A novel approach to chiral, nonracemic pyrrolidines by 5-exo-trig diastereoselective radical cyclization on acrylamides derived from (-)-8- aminomenthol

α,β-Unsaturated amides supported on perhydro-1,3-benzoxazines derived from (-)-8-aminomenthol as chiral auxiliaries undergo regio- and stereoselective 5-exo-trig radical cyclization leading to diastereomeric five-membered lactams. These cyclization products are transformed into enantiopure 3,4-disubstituted pyrrolidines by reduction with aluminum hydride followed by removal of the menthol appendage.