235099-09-9Relevant articles and documents
AS-924, a novel orally active bifunctional prodrug of ceftizoxime. Synthesis and relationship between physicochemical properties and oral absorption
Kasai, Masayasu,Hatano, Satoru,Kitagawa, Meiko,Yoshimi, Akihisa,Nishimura, Ken-Ichi,Mori, Nobuhiro,Sakai, Atsushi,Sugihara, Taisuke
, p. 1081 - 1088 (1999)
Ceftizoxime (CZX), a parenteral cephalosporin, has potent and broad antibacterial activity. To improve its oral absorption, we synthesized a series of monofunctional and bifunctional prodrugs of CZX. In rabbits, urinary recovery after oral administration