AS-924, a novel orally active bifunctional prodrug of ceftizoxime. Synthesis and relationship between physicochemical properties and oral absorption

DOI: 10.1248/cpb.47.1081

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1081 - 1088 (1999)

Update date:2022-08-03

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Authors:

Kasai, Masayasu

Hatano, Satoru

Kitagawa, Meiko

Yoshimi, Akihisa

Nishimura, Ken-Ichi

Mori, Nobuhiro

Sakai, Atsushi

Sugihara, Taisuke

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Article abstract of DOI:10.1248/cpb.47.1081

Ceftizoxime (CZX), a parenteral cephalosporin, has potent and broad antibacterial activity. To improve its oral absorption, we synthesized a series of monofunctional and bifunctional prodrugs of CZX. In rabbits, urinary recovery after oral administration

Full text of DOI:10.1248/cpb.47.1081

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