1612145-76-2Relevant academic research and scientific papers
Lithium binaphtholate-catalyzed enantioselective enyne addition to ketones: Access to enynylated tertiary alcohols
Cai, Hua,Nie, Jing,Zheng, Yan,Ma, Jun-An
, p. 5484 - 5493 (2014/07/08)
A new catalytic enantioselective enyne addition to ketones has been developed. In the presence of chiral lithium binaphtholate, the addition reaction proceeded smoothly to produce a series of enynylated tertiary alcohols in up to 96% yield and 94% enantiomeric excess. Convenient transformation of the adduct via Pauson-Khand cycloaddition reaction afforded the bicyclic product without detectable loss of enantioselectivity. Furthermore, catalytic asymmetric enyne addition to trifluoromethylketone was applied in the synthesis of the Efavirenz analogue.
