23522-38-5 Usage
General Description
3-(3-methylphenyl)-2-sulfanylidene-thiazolidin-4-one, also known as pioglitazone, is a chemical compound commonly used as an oral medication for the treatment of type 2 diabetes. It belongs to the thiazolidinedione class of drugs and works by decreasing insulin resistance in the body. Pioglitazone is a synthetic compound that has been shown to improve blood sugar control and lower the risk of heart attack or stroke in people with type 2 diabetes. It is also being studied for its potential use in treating other conditions such as polycystic ovary syndrome and neurodegenerative diseases. However, it is important to note that pioglitazone may also have some serious side effects, such as an increased risk of bladder cancer and heart failure, and should be used under the supervision of a healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 23522-38-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,5,2 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 23522-38:
(7*2)+(6*3)+(5*5)+(4*2)+(3*2)+(2*3)+(1*8)=85
85 % 10 = 5
So 23522-38-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NOS2/c1-7-3-2-4-8(5-7)11-9(12)6-14-10(11)13/h2-5H,6H2,1H3
23522-38-5Relevant articles and documents
Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis
Sonawane,Verkman
experimental part, p. 8187 - 8195 (2009/04/11)
The thiazolidinone 3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone (CFTRinh-172) inhibits cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel conductance with submicromolar affinity and blocks cholera toxin-induced intestinal fluid secretion. Fifty-eight CFTRinh-172 analogs were synthesized to identify CFTR inhibitors with improved water solubility, exploring modifications in its two phenyl rings, thiazolidinone core, and core-phenyl connectors. Greatest CFTR inhibition potency was found for 3-CF3 and polar group-substituted-phenyl rings, and a thiazolidinone core. Two compounds with ～1 μM CFTR inhibition potency and solubility >180 μM (>10-fold more than CFTRinh-172) were identified: Tetrazolo-172, containing 4-tetrazolophenyl in place of 4-carboxyphenyl, and Oxo-172, containing thiazolidinedione in place of the thiazolidinone core. These water soluble thiazolidinone analogs had low cellular toxicity. The improved water solubility of Tetrazolo- and Oxo-172 make them potential lead candidates for therapy of secretory diarrheas and polycystic kidney disease.
