23522-47-6

Usage

InChI:InChI=1/C9H6ClNOS2/c10-6-3-1-2-4-7(6)11-8(12)5-14-9(11)13/h1-4H,5H2

Upstream product

• 2740-81-0 2-chlorophenylisothiocyanate 
• 68-11-1 mercaptoacetic acid 
• 623-51-8 ethyl 2-sulfanylacetate 
• 66065-30-3 ammonium salt of N-o-chlorophenylamino dithiocarbamic acid 
• 79-11-8 chloroacetic acid 
• 95-51-2 o-chloroaniline 
• 5344-82-1 o-chlorophenylthiourea 
• 1122513-16-9 C₉H₇ClNO₂S₂^(1-)*Na⁽¹⁺⁾ 
• 3926-62-3 sodium monochloroacetic acid 

Downstream Products

• 158979-72-7 3-(2-Chloro-phenyl)-5-[1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-2-thioxo-thiazolidin-4-one 

Relevant academic research and scientific papers

A New Synthesis Strategy for Rhodanine and Its Derivatives

Rhodanine and its derivatives have been known as privileged structures in pharmacological research because of their wide spectrum of biological activities, but the synthesis method of rhodanine skeleton is limited. In this paper, not only rhodanine skeleton, but also N -aryl rhodanines can be directly prepared via the reaction of thioureas and thioglycolic acid in one step catalyzed by protic acid, which provides a new approach of the synthesis of rhodanine and its derivatives. The developed strategy is straightforward, efficient, atom economical, and convenient in good yields.

Novel rhodanines with anticancer activity: Design, synthesis and CoMSIA study

Three different series of some novel N-substituted rhodanines were designed for anticancer activity and prepared from the corresponding dithiocarbamates. The synthesized compounds were analyzed by IR, NMR and MASS to confirm their structures. All the titl

Catalytic dynamic spectrofluorimetry determination of trace antimony using new type arsenoxylphenylazo rhodanine

A precise, simple, new spectrofluorimetry method is proposed for determination of trace antimony which is based on the reaction between potassium periodate and the new type fluorescent reagent 3-o-chlorophenyl-5-(2′- arsenoxylphenylazo) rhodanine (2ClRAAP

Axially chiral N-(o-aryl)-2-thioxo-oxazolidine-4-one and rhodanine derivatives: enantiomeric separation and determination of racemization barriers

Axially chiral 5,5-dimethyl-3-(o-aryl)rhodanine, 3-(o-aryl)rhodanine and 5,5-dimethyl-3-(o-aryl)-2-thioxo-4-oxazolidinone derivatives have been synthesized as racemates and the energy barriers to enantiomerization have been determined by dynamic 1/s

Synthesis and NMR studies of chiral 4-oxazolidinones and rhodanines

Sterically hindered N-(o-tolyl) and N-(o-chlorophenyl) substituted 2-thioxo-4-oxazolidinones 1 and-thiazolidinones (rhodanines) 2 forming enantiomers by partial rotation around the C - N bond are synthesized. Their chirality is proven by the presence of diastereotopic protons (or carbon atoms) detected by 1H or 13C NMR (1c, 2c). In the presence of (S)(+)-1-(9-anthryl)-2,2,2-trifluoroethanol as an auxilliary the enantiomers showed 1H shift differences of 0.01 ppm for otherwise isochronous nuclei.