23555-00-2 Usage
Uses
Used in Cell Biology Research:
HOECHST 34580 is used as a fluorescent stain for visualizing cell nuclei, aiding researchers in the study of cellular and subcellular structures. Its application is crucial for observing and analyzing cell division and cell cycle progression due to its ability to bind to DNA and emit a blue fluorescence.
Used in Neuroscience Research:
In the field of neuroscience, HOECHST 34580 serves as a vital tool for staining and visualizing the nuclei of neurons, contributing to the understanding of neural development, connectivity, and function.
Used in Diagnostic Tool Development:
HOECHST 34580 is used as a component in the development of diagnostic tools for identifying and quantifying DNA in various biological samples. Its high specificity and fluorescence properties make it suitable for accurate and sensitive DNA detection.
Used in Organelle Labeling:
HOECHST 34580 is also used to label DNA in organelles such as mitochondria, providing insights into mitochondrial DNA replication, transcription, and its role in cellular processes.
Check Digit Verification of cas no
The CAS Registry Mumber 23555-00-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,5,5 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 23555-00:
(7*2)+(6*3)+(5*5)+(4*5)+(3*5)+(2*0)+(1*0)=92
92 % 10 = 2
So 23555-00-2 is a valid CAS Registry Number.
23555-00-2Relevant academic research and scientific papers
Radioprotectors
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Page/Page column 20, (2009/04/23)
A compound of the formula (Ib): wherein X is NCH3, Y is N, Z is N, R3 is N(CH3)2, and (a) R1 is CH3, R2, R4 and R5 to R11 are hydrogen or (b) R5 is CH3 and R1, R2, R4 and R6 to R11 are hydrogen, and salts and tautomers thereof.
DNA Binding Compounds. VI. Synthesis and Characterization of 2,5'-Disubstituted Bibenzimidazoles Related to the DNA Minor Groove Hoechst 33258
Kelly, David P.,Bateman, Stuart A.,Hook, Robert J.,Martin, Roger F.,Reum, Monica E.,et al.
, p. 1751 - 1770 (2007/10/02)
A series of compounds have been synthesized in which the basic 2-phenylbibenzimidazole structure of Hoechst 33258 has been modified to include various combinations of bromo, iodo, methoxy, amino, alkylamino and nitro groups in the terminal phenyl ring.Both sequential and convergent synthetic routs have been followed using coupling reactions of both imino ethers and aldehydes to 1,2-diamines.All these compounds were characterized by a combination of f.a.b. mass spectrometry and 1H and 13C n.m.r. spectroscopy including inverse detection of long-range heteronuclear CH correlations (HMBC).
